Study of acid-base equilibria of fleroxacin

被引：16

作者：

Popovic, G ^{[1
]}

Milovanovic, L ^{[1
]}

Kapetanovic, V ^{[1
]}

机构：

[1] Univ Belgrade, Fac Pharm, Inst Inorgan & Analyt Chem, YU-11000 Belgrade, Yugoslavia

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 18卷 / 4-5期

关键词：

fleroxacin; acidity constants; spectrophotometry; potentiometry;

D O I：

10.1016/S0731-7085(98)00281-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The acid-base equilibria of fleroxacin were studied by means of potentiometry and spectrophotometry. It was established that fleroxacin undergoes a complex acid-base equilibrium due to its zwitterionic nature and two proton-binding sites of similar acidity. The stoichiometric equilibrium constants were determined at 25 degrees C and constant ionic strength 0.1 M (NaCl). The acidity constants pK(1) = 5.59 +/- 0.01 and pK(2) = 8.08 +/- 0.04 were found by potentiometry, and pK(1) = 5.61 +/- 0.03 and pK(2) = 8.11 +/- 0.06 by spectrophotometry. The distribution diagram of the corresponding ionic species is given. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：859 / 863

页数：5

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