Anti-aging effects of extracts prepared from salmon nasal cartilage in hairless mice

被引：13

作者：

Goto, Masashi ^{[2
,3
]}

Ito, Seiko ^{[4
]}

Kato, Yoji ^{[4
]}

Yamazaki, Shota ^{[1
]}

Yamamoto, Kazushi ^{[2
]}

Katagata, Yohtaro ^{[1
,3
]}

机构：

[1] Hirosaki Univ, Dept Biochem & Biotechnol, Fac Agr & Life Sci, Hirosaki, Aomori 0368561, Japan

[2] Sunstar Inc, R&D Dept, Takatsuki, Osaka 5691195, Japan

[3] Iwate Univ, United Grad Sch Agr Sci, Morioka, Iwate 0208550, Japan

[4] Hirosaki Univ, Fac Educ, Food Sci Lab, Hirosaki, Aomori 0368560, Japan

来源：

MOLECULAR MEDICINE REPORTS | 2011年 / 4卷 / 05期

关键词：

proteoglycan; salmon nasal cartilage; anti-aging function; BONE-MINERAL DENSITY; INDUCED SKIN DAMAGE; BARRIER FUNCTIONS; IRRADIATION; INGESTION; GELATIN; PROTEOGLYCAN; INDUCTION; WATER;

D O I：

10.3892/mmr.2011.498

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The skin anti-aging effects of orally administered salmon nasal cartilage extract (SNCE), which includes abundant proteoglycan, were investigated using a hairless mouse skin-aging model, in which aging was caused by repetitive ultraviolet B (UV-B) irradiation. Physiological analysis of the skin surface following repetitive UV-B irradiation of 8 weeks revealed inhibition of erythema levels and reduction of transepidermal water loss (TEWL) due to oral administration of SNCE. Similarly, inhibitory actions of epidermal and dermal hypertrophy were revealed by hematoxylin and eosin staining. Furthermore, effects on the hydration level of the skin surface by SNCE administration were indicated at 4 weeks of UV-B irradiation, but greater effects were not apparent. These results indicate that SNCE may serve as an anti-aging agent for healthy skin.

引用

页码：779 / 784

页数：6

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