Stereoselective total synthesis of (-)-(5S,8R,13S,16R)-pyrenophorol

被引：12

作者：

Edukondalu, Perugu ^{[1
]}

Sreenivasulu, Reddymasu ^{[1
]}

Chiranjeevi, Barreddi ^{[2
]}

Kumar, Vuppula Naresh ^{[3
]}

Raju, Rudraraju Ramesh ^{[1
]}

机构：

[1] Acharya Nagarjuna Univ, Dept Chem, Nagarjuna Nagar 522510, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Inorgan & Phys Chem Div, Hyderabad 500007, Andhra Pradesh, India

[3] Sri Chaitanya PG Coll, Dept Chem, Godavarikhani 505209, India

来源：

MONATSHEFTE FUR CHEMIE | 2015年 / 146卷 / 08期

关键词：

(S)-Propylene epoxide; Cross-metathesis reaction; Intermolecular Mitsunobu cyclization; (-)-Pyrenophorol; MACRODIOLIDE PYRENOPHOROL; COLLETOTRICHUM-CAPSICI; SECONDARY METABOLITES; KINETIC RESOLUTION; TERMINAL EPOXIDES; (-)-PYRENOPHOROL; COLLETODIOL; DILACTONE; PRODUCTS;

D O I：

10.1007/s00706-014-1406-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The total synthesis of 16-membered C (2)-symmetric dilactone (-)-(5S,8R,13S,16R)-pyrenophorol was accomplished starting from enantiomerically pure propylene oxide prepared by hydrolytic kinetic resolution of (+/-)-propylene oxide with key steps of cross-metathesis and intermolecular Mitsunobu cyclization for the construction of macrolactone.

引用

页码：1309 / 1314

页数：6

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