Prevention of colorectal cancer: effects of current methods and perspectives for the future

In the future, screening for colorectal cancer will be noninvasive. These tests must have high specificity to reduce unnecessary invasive examinations and a high enough sensitivity to exclude false-negative results. To date, no blood test fullfills these recommendations. Currently, the best noninvasive approach is the combination of clinical and familial risk stratification combined with genome-wide analysis (GWA). Next generation sequencing (NGS) and the use of artificial intelligence will lead to safe noninvasive screening for not only colorectal cancer but also for other cancers.