Angiopoietin-1 and Endostatin Levels in Cord Plasma Predict the Development of Bronchopulmonary Dysplasia in Preterm Infants

被引：27
|
作者：
Mohamed, Walid Abdel Wahab [1 ,2 ]
Niyazy, Walid H. [3 ,4 ]
Mahfouz, Ahmed A. [5 ]
机构：
[1] King Khalid Univ, Coll Med, Dept Pediat, Abha, Saudi Arabia
[2] El Minya Univ, Dept Pediat, El Minya, Egypt
[3] King Khalid Univ, Coll Med, Dept Biochem, Abha, Saudi Arabia
[4] El Minofya Univ, Dept Biochem, El Minofya, Egypt
[5] King Khalid Univ, Coll Med, Dept Community Med, Abha, Saudi Arabia
来源：
JOURNAL OF TROPICAL PEDIATRICS | 2011年 / 57卷 / 05期
关键词：
Angiopoietin-1; endostatin; bronchopulmonary dysplasia; preterm infants; ENDOTHELIAL GROWTH-FACTOR; PREMATURE-INFANTS; ANGIOGENESIS; LUNG; INJURY;
D O I：
10.1093/tropej/fmq112
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Objective: To determine whether angiopoietin-1 and endostatin levels in the cord blood could predict the subsequent development of bronchopulmonary dysplasia (BPD) in preterm infants. Patients and Methods: A total of 102 preterm (gestational age <= 32 weeks) infants (28 infants developed BPD and 74 had no BPD) were enrolled in the study. Cord plasma levels of angiopoietin-1 and endostatin were measured by enzyme-linked immunosorbent assay. Results: Preterm infants who subsequently developed BPD had significantly lower cord plasma levels of angiopoietin-1 than those who did not (p<0.001). Our results showed that cord plasma levels of endostatin were significantly higher in infants with BPD than in those without (p<0.001). In infants with BPD, angiopoietin-1 levels in cord plasma correlated negatively with endostatin (r = -0.48; p = 0.008). Conclusion: In preterm infants, low-angiopoietin-1 and high-endostatin levels in cord plasma at birth predict the subsequent development of BPD.
引用
收藏
页码：385 / 388
页数：4
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