Transfusion Medicine and the Pregnant Patient

被引:6
|
作者
Lee, Alfred Ian [2 ]
Kaufman, Richard M. [1 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02118 USA
关键词
Hemolytic disease of the fetus and newborn; Fetomaternal hemorrhage; Fetal and neonatal alloimmune thrombocytopenia; Postpartum hemorrhage; Obstetric hemorrhage; Disseminated intravascular coagulation; Recombinant factor VIIa; Parvovirus B19; RECOMBINANT-FACTOR-VIIA; ACTIVATED FACTOR-VII; NEONATAL ALLOIMMUNE THROMBOCYTOPENIA; DISSEMINATED INTRAVASCULAR COAGULATION; ANTI-D IMMUNOGLOBULIN; RH HEMOLYTIC-DISEASE; POSTPARTUM HEMORRHAGE; IMMUNE THROMBOCYTOPENIA; PLATELET ANTIGENS; MATERNAL ALLOIMMUNIZATION;
D O I
10.1016/j.hoc.2011.02.002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Alloimmunity in pregnancy is the basis for two of the major complications of pregnancy in transfusion medicine: hemolytic disease of the fetus and newborn (HDFN), and fetal and neonatal alloimmune thrombocytopenia (FNAIT). Use of Rh(D) immune globulin has dramatically reduced the incidence of HDFN in Rh(D)-mismatched pregnancies. Treatment of HDFN may involve intrauterine transfusion, with fetal and neonatal survival rates of 70% to 90%. Treatments for FNAIT include immune globulin, steroids, or in severe cases, intrauterine platelet transfusions. Transfusion medicine is central to the management of pregnancy-associated complications such as postpartum hemorrhage, parvovirus B19 infection, hemoglobinopathies, and aplastic anemia.
引用
收藏
页码:393 / +
页数:22
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