Three unusual indole diketopiperazine alkaloids from a terrestrial-derived endophytic fungus, Aspergillus sp.

被引：12

作者：

Lhamo, Sonum ^{[1
]}

Wang, Xiao-Bing ^{[1
]}

Li, Tian-Xiao ^{[1
]}

Wang, Ying ^{[1
]}

Li, Zhong-Rui ^{[1
]}

Shi, Ya-Min ^{[1
]}

Yang, Ming-Hua ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Indole diketopiperazine alkaloids; Tryptanthrin; Aspergillus sp; Aspertryptanthrins A-C; BIOACTIVE METABOLITES; FUMIGATUS; ANTIFUNGAL;

D O I：

10.1016/j.tetlet.2015.04.058

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new indole diketopiperazine alkaloids, named aspertryptanthrins A-C (1-3), were isolated from a terrestrial-derived endophytic fungus Aspergillus sp. Their structures were established by spectral methods, and the absolute configurations were determined via the Rh-2(OCOCF3)(4) induced ECD spectra and the comparison of experimental and calculated ECD spectra. Belonging to the indole diketopiperazine alkaloids, these compounds represented first samples containing tryptanthrin skeleton formed by tryptophan residue and anthranilate unite, while aspertryptanthrin C (3) was particularly an interesting molecular skeleton containing a rare 16-membered ring. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：2823 / 2826

页数：4

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