HSV-1 DNA Replication-Coordinated Regulation by Viral and Cellular Factors

被引：33
|
作者：
Packard, Jessica E. [1 ]
Dembowski, Jill A. [1 ]
机构：
[1] Duquesne Univ, Dept Biol Sci, Pittsburgh, PA 15282 USA
来源：
VIRUSES-BASEL | 2021年 / 13卷 / 10期
关键词：
herpes simplex virus; HSV-1; DNA replication; replication fork; recombination; SIMPLEX-VIRUS TYPE-1; ORIGIN-BINDING-PROTEIN; HERPESVIRUS MACROMOLECULAR-SYNTHESIS; MISMATCH REPAIR PROTEINS; HELICASE-PRIMASE; NUCLEAR ANTIGEN; POLYMERASE PROCESSIVITY; CATALYTIC SUBUNIT; ALKALINE NUCLEASE; THYMIDINE KINASE;
D O I：
10.3390/v13102015
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that is coordinated with the cellular DNA damage response, repair and recombination of the viral genome, and viral gene transcription. HSV-1 encodes its own DNA replication machinery, including an origin binding protein (UL9), single-stranded DNA binding protein (ICP8), DNA polymerase (UL30), processivity factor (UL42), and a helicase/primase complex (UL5/UL8/UL52). In addition, HSV-1 utilizes a combination of accessory viral and cellular factors to coordinate viral DNA replication with other viral and cellular processes. The purpose of this review is to outline the roles of viral and cellular proteins in HSV-1 DNA replication and replication-coupled processes, and to highlight how HSV-1 may modify and adapt cellular proteins to facilitate productive infection.
引用
收藏
页数：15
相关论文
共 50 条
  • [21] INVERSION EVENTS IN THE HSV-1 GENOME ARE DIRECTLY MEDIATED BY THE VIRAL-DNA REPLICATION MACHINERY AND LACK SEQUENCE SPECIFICITY
    WEBER, PC
    CHALLBERG, MD
    NELSON, NJ
    LEVINE, M
    GLORIOSO, JC
    CELL, 1988, 54 (03) : 369 - 381
  • [22] Evaluation of infection parameters in the production of replication-defective HSV-1 viral vectors
    Ozuer, A
    Wechuck, JB
    Russell, B
    Wolfe, D
    Goins, WF
    Glorioso, JC
    Ataai, MM
    BIOTECHNOLOGY PROGRESS, 2002, 18 (03) : 476 - 482
  • [23] THE CYTOKINE, LEUKOREGULIN, INHIBITS HSV-1 REPLICATION
    PERCOPO, C
    DETRICK, B
    EVANS, C
    HOOKS, JJ
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1992, 33 (04) : 787 - 787
  • [24] Control of cellular gene expression during herpes simplex virus 1 (HSV-1) replication
    Roizman, Bernard
    JOURNAL OF NEUROVIROLOGY, 2004, 10 : 32 - 32
  • [25] Cellular miR-101-1 Reduces Efficiently the Replication of HSV-1 in HeLa Cells
    Ehdaei, Bahar Sadegh
    Pirouzmand, Ahmad
    Shabani, Mehdi
    Mirzaei, Arezoo
    Moghim, Sharareh
    INTERVIROLOGY, 2021, 64 (02) : 88 - 95
  • [26] VIRAL INTERFERENCE BY A VARIANT HSV-1 PARTICLE - A SPECIFIC INTERFERENCE WITH DNA MATURATION
    KUMEL, G
    HENNESSTEGMANN, B
    GRAY, CP
    SCHRODER, CH
    HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1981, 362 (03): : 217 - 218
  • [27] CYTOKINE REGULATION OF IMMUNITY TO HSV-1
    GEBHARDT, BM
    WALL, RA
    FASEB JOURNAL, 1992, 6 (04): : A1221 - A1221
  • [28] Innate lymphotoxin receptor mediated signaling promotes HSV-1 associated neuroinflammation and viral replication
    Liang, Yong
    Yang, Kaiting
    Guo, Jingya
    Wroblewska, Joanna
    Fu, Yang-Xin
    Peng, Hua
    SCIENTIFIC REPORTS, 2015, 5
  • [29] Innate lymphotoxin receptor mediated signaling promotes HSV-1 associated neuroinflammation and viral replication
    Yong Liang
    Kaiting Yang
    Jingya Guo
    Joanna Wroblewska
    Yang-Xin Fu
    Hua Peng
    Scientific Reports, 5
  • [30] THE 65 K DNA-BINDING PROTEIN APPEARS EARLY IN HSV-1 REPLICATION
    SCHENK, P
    LUDWIG, H
    ARCHIVES OF VIROLOGY, 1988, 102 (1-2) : 119 - 123
12345