The BAFFling function of Syk in B-cell homeostasis

被引：3
|
作者：
Koenigsberger, Sebastian [1 ]
Kiefer, Friedemann [1 ]
机构：
[1] Max Planck Inst Mol Biomed, Mammalian Cell Signaling Lab, D-48149 Munster, Germany
来源：
EMBO JOURNAL | 2015年 / 34卷 / 07期
关键词：
TYROSINE KINASE; RECEPTOR; SURVIVAL; SIGNALS;
D O I：
10.15252/embj.201591120
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The TNF receptor family member BAFFR is essential for providing mature B cells with pro-survival signals and has recently been claimed to transduce these, though not exclusively, via a Syk-dependent signaling hub that feeds into ERK/AKT activation. In this issue of The EMBO Journal, Hobeika et al (2015) describe a synergistic pro-survival scenario involving BAFFR and CD19, which remains functional under Syk null conditions and is able to maintain mature B-cell survival. The authors hence propose a BAFFR-/CD19-driven mechanism to act in parallel with homeostatic NF-kappa B/AKT activation in non-stimulated B cells.
引用
收藏
页码：838 / 840
页数：3
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