Neoadjuvant Therapy of Colorectal Liver Metastases: Lessons Learned from Clinical Trials

被引：14

作者：

Brouquet, Antoine ^{[1
]}

Nordlinger, Bernard ^{[1
]}

机构：

[1] Univ Versailles St Quentin Yvelines, Hop Ambroise Pare, AP HP, Dept Digest & Oncol Surg, Versailles, France

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 102卷 / 08期

关键词：

colorectal cancer; liver metastases; chemotherapy; OXALIPLATIN-BASED CHEMOTHERAPY; MULTICENTER RANDOMIZED-TRIAL; HEPATIC ARTERIAL INFUSION; LONG-TERM SURVIVAL; PHASE-III TRIAL; PREOPERATIVE CHEMOTHERAPY; SURGICAL RESECTION; 1ST-LINE TREATMENT; PATHOLOGICAL RESPONSE; FOLINIC ACID;

D O I：

10.1002/jso.21657

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neoadjuvant chemotherapy is increasingly used to improve outcome in patients with colorectal liver metastases (CLM). In patients with unresectable CLM, recent clinical trials evaluate the ability of chemotherapy to increase the resectability rate. In patients with resectable CLM, the objective is to decrease the risk of recurrence after hepatectomy that still remains elevated despite the improvement of the surgical technique. A multidisciplinary approach of patients with CLM is desirable whatever the initial status of resectability. J. Surg. Oncol. 2010; 102: 932-936. (C) 2010 Wiley-Liss, Inc.

引用

页码：932 / 936

页数：5

共 50 条

[41] Neoadjuvant therapy concepts for liver metastases
Folprecht, G.
Bechstein, W. O.
CHIRURG, 2011, 82 (11): : 989 - 994
[42] Neoadjuvant chemotherapy in treatment of patients with liver metastases from colorectal cancer
Polishchuk, L.
Strojakovski, D.
Sekacheva, M.
Skipenko, O.
ANNALS OF ONCOLOGY, 2008, 19 : 38 - 38
[43] Clinical Trials From the Other Side: Lessons Learned by a Clinician Venturing Into a Clinical Trials Unit
Bhattacharya, I. S.
Bliss, J. M.
CLINICAL ONCOLOGY, 2019, 31 (07) : 420 - 423
[44] Clinical holds for cell and gene therapy trials: Risks, impact, and lessons learned
Wills, Carolyn A.
Drago, Daniela
Pietrusko, Robert G.
MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT, 2023, 31
[45] Simulation of clinical trials: Lessons learned.
Ko, HC
Jang, IJ
Li, J
Bies, RR
Gobburu, JVS
Peck, CC
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2000, 67 (02) : 162 - 162
[46] From the Laboratory to Clinical Trials and Back Again: Lessons Learned from HIV Prevention Trials
Sibeko, Sengeziwe
Makvandi-Nejad, Shokouh
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2013, 69 : 106 - 115
[47] Endothelin Antagonists in Clinical Trials: Lessons Learned
Barton, Matthias
Kohan, Donald E.
ENDOTHELIN IN RENAL PHYSIOLOGY AND DISEASE, 2011, 172 : 255 - 260
[48] Neoadjuvant Chemotherapy Prior to Resection of Colorectal Liver Metastases
Brouquet, Antoine
Nordlinger, Bernard
CURRENT COLORECTAL CANCER REPORTS, 2012, 8 (03) : 210 - 216
[49] Resection of colorectal liver metastases following neoadjuvant chemotherapy
Chiappa, A.
Bertani, E.
Biffi, R.
Pace, U.
Viale, G.
Pruneri, G.
Zampino, G.
Fazio, N.
Orsi, F.
Bonomo, G.
Monfardini, L.
Della Vigna, P.
Andreoni, B.
ECANCERMEDICALSCIENCE, 2007, 1
[50] Neoadjuvant treatment of clearly resectable colorectal liver metastases
McCain, D. A.
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)

← 1 2 3 4 5 →