Neoadjuvant Therapy of Colorectal Liver Metastases: Lessons Learned from Clinical Trials

被引：14
|
作者：
Brouquet, Antoine [1 ]
Nordlinger, Bernard [1 ]
机构：
[1] Univ Versailles St Quentin Yvelines, Hop Ambroise Pare, AP HP, Dept Digest & Oncol Surg, Versailles, France
来源：
JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 102卷 / 08期
关键词：
colorectal cancer; liver metastases; chemotherapy; OXALIPLATIN-BASED CHEMOTHERAPY; MULTICENTER RANDOMIZED-TRIAL; HEPATIC ARTERIAL INFUSION; LONG-TERM SURVIVAL; PHASE-III TRIAL; PREOPERATIVE CHEMOTHERAPY; SURGICAL RESECTION; 1ST-LINE TREATMENT; PATHOLOGICAL RESPONSE; FOLINIC ACID;
D O I：
10.1002/jso.21657
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neoadjuvant chemotherapy is increasingly used to improve outcome in patients with colorectal liver metastases (CLM). In patients with unresectable CLM, recent clinical trials evaluate the ability of chemotherapy to increase the resectability rate. In patients with resectable CLM, the objective is to decrease the risk of recurrence after hepatectomy that still remains elevated despite the improvement of the surgical technique. A multidisciplinary approach of patients with CLM is desirable whatever the initial status of resectability. J. Surg. Oncol. 2010; 102: 932-936. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码：932 / 936
页数：5
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