Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1

被引：23
|
作者：
Jetter, Michele C.
Youngman, Mark A.
McNally, James J.
McDonnell, Mark E.
Zhang, Sui-Po
Dubin, Adrienne E.
Nasser, Nadia
Codd, Ellen E.
Flores, Christopher M.
Dax, Scott L.
机构：
[1] Johnson & Johnson Pharmaceut Res & Dev, Spring House, PA 19477 USA
[2] Johnson & Johnson Pharmaceut Res & Dev, San Diego, CA 92121 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 22期
关键词：
TRPV1; antagonists; tetralin ureas;
D O I：
10.1016/j.bmcl.2007.09.036
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We report on a series of alpha-substituted-beta-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6160 / 6163
页数：4
相关论文
共 50 条
  • [21] TRPV1 Antagonists as Potential Antitussive Agents
    Robbie L. McLeod
    Craig C. Correll
    Yanlin Jia
    John C. Anthes
    Lung, 2008, 186 : 59 - 65
  • [22] Targeting TRPV1 by antagonists for pain relief
    Trevisani, M.
    NEUROPEPTIDES, 2009, 43 (05) : 451 - 451
  • [23] MEDI 316-Ureas substituted with partially reduced heteroaromatics as novel transient receptor potential vanilloid 1 (TRPV1) antagonists for the treatment of pain
    Gomtsyan, Arthur
    Bayburt, Erol K.
    Schmidt, Robert G.
    Daanen, Jerome F.
    Koenig, John R.
    Latshaw, Steven P.
    Jinkerson, Tammie K.
    Brown, Brian S.
    Mcdonald, Heath A.
    Bianchi, Bruce
    Puttfarcken, Pamela
    Moreland, Robert
    Cui, Minglei
    Honore, Prisca
    St George, Karen
    Darbyshire, John F.
    Marsh, Kennan C.
    Faltynek, Connie R.
    Lee, Chih-Hung
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [24] Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists
    Li, Fu-Nan
    Kim, Nam-Jung
    Paek, Seung-Mann
    Kwon, Do-Yeon
    Min, Kyung Hoon
    Jeong, Yeon-Su
    Kim, Sun-Young
    Park, Young-Ho
    Kim, Hee-Doo
    Park, Hyeung-Geun
    Suh, Young-Ger
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (10) : 3557 - 3567
  • [25] Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists
    Appendino, G
    Harrison, S
    De Petrocellis, L
    Daddario, N
    Bianchi, F
    Moriello, AS
    Trevisani, M
    Benvenuti, F
    Geppetti, P
    Di Marzo, V
    BRITISH JOURNAL OF PHARMACOLOGY, 2003, 139 (08) : 1417 - 1424
  • [26] Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade
    Gavva, Narender R.
    Bannon, Anthony W.
    Hovland, David N., Jr.
    Lehto, Sonya G.
    Klionsky, Lana
    Surapaneni, Sekhar
    Immke, David C.
    Henley, Charles
    Arik, Leyla
    Bak, Annette
    Davis, James
    Ernst, Nadia
    Hever, Gal
    Kuang, Rongzhen
    Shi, Licheng
    Tamir, Rami
    Wang, Jue
    Wang, Weiya
    Zajic, Gary
    Zhu, Dawn
    Norman, Mark H.
    Louis, Jean-Claude
    Magal, Ella
    Treanor, James J. S.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007, 323 (01): : 128 - 137
  • [27] TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists
    Cui, M.
    Honore, P.
    Zhong, C.
    Gauvin, D.
    Mikusa, J.
    Hernandez, G.
    Chandran, P.
    Gomtsyan, A.
    Brown, B.
    Bayburt, E. K.
    Marsh, K.
    Bianchi, B.
    McDonald, H.
    Niforatos, W.
    Neelands, T. R.
    Moreland, R. B.
    Decker, M. W.
    Lee, C. -H.
    Sullivan, J. P.
    Faltynek, C. R.
    JOURNAL OF NEUROSCIENCE, 2006, 26 (37): : 9385 - 9393
  • [28] Emerging therapies for atopic dermatitis: TRPV1 antagonists
    Bonchak, Jonathan G.
    Swerlick, Robert A.
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2018, 78 (03) : S63 - S66
  • [29] Benzamide-type vanilloid (TRPV1) antagonists
    Appendino, G
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2006, 16 (04) : 549 - 553
  • [30] Discovery of Dual TRPA1 and TRPV1 Antagonists as Novel Therapeutic Agents for Pain
    Do, Nayeon
    Zuo, Dongxu
    Kim, Miri
    Kim, Minseok
    Ha, Hee-Jin
    Blumberg, Peter M.
    Ann, Jihyae
    Hwang, Sun Wook
    Lee, Jeewoo
    PHARMACEUTICALS, 2024, 17 (09)
12345