Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1

被引：23
|
作者：
Jetter, Michele C.
Youngman, Mark A.
McNally, James J.
McDonnell, Mark E.
Zhang, Sui-Po
Dubin, Adrienne E.
Nasser, Nadia
Codd, Ellen E.
Flores, Christopher M.
Dax, Scott L.
机构：
[1] Johnson & Johnson Pharmaceut Res & Dev, Spring House, PA 19477 USA
[2] Johnson & Johnson Pharmaceut Res & Dev, San Diego, CA 92121 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 22期
关键词：
TRPV1; antagonists; tetralin ureas;
D O I：
10.1016/j.bmcl.2007.09.036
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We report on a series of alpha-substituted-beta-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6160 / 6163
页数：4
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