Replication and partitioning of the broad-host-range plasmid RK2

被引：34
|
作者：
Kolatka, Katarzyna [1 ]
Kubik, Slawomir [1 ]
Rajewska, Magdalena [1 ]
Konieczny, Igor [1 ]
机构：
[1] Univ Gdansk, Intercollegiate Fac Biotechnol, Dept Mol & Cellular Biol, PL-80822 Gdansk, Poland
来源：
PLASMID | 2010年 / 64卷 / 03期
关键词：
RK2; plasmid; Replication initiation; Partitioning; Global regulatory network; COPY-NUMBER CONTROL; DNA-POLYMERASE-III; TRANSCRIPTIONAL REPRESSOR ACTIVITY; DISTANTLY RELATED BACTERIA; GRAM-NEGATIVE BACTERIA; INITIATOR PROTEIN TRFA; CENTRAL CONTROL REGION; GLOBAL REGULATOR KORB; INCP-ALPHA PLASMIDS; PARB HOMOLOG KORB;
D O I：
10.1016/j.plasmid.2010.06.004
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The broad-host-range plasmid RK2 has been a model for studying DNA metabolism in bacteria for many years. It is used as a vector allowing genetic manipulations in numerous bacterial species. The RK2 genome encodes several genes providing the plasmid with diverse functions allowing for its stable maintenance in a variety of bacterial hosts. This review will focus on two processes indispensable for plasmid DNA maintenance. We will summarize recent understanding of the molecular mechanisms contributing to the RK2 DNA replication and partitioning. (C) 2010 Elsevier Inc. All rights reserved.
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页码：119 / 134
页数：16
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