Fatty Acids Induce Stemness in the Stromal Cells of a CT26 Mouse Tumor Model

被引：4
|
作者：
Kawahara, Isao [1 ,2 ]
Mori, Takuya [1 ,2 ]
Goto, Kei [1 ,3 ]
Fujii, Kiyomu [1 ]
Ohmori, Hitoshi [1 ]
Kishi, Shingo [1 ]
Fujiwara-Tani, Rina [1 ]
Kuniyasu, Hiroki [1 ]
机构：
[1] Nara Med Univ, Dept Mol Pathol, 840 Shijo Cho, Kashihara, Nara 6348521, Japan
[2] Hanna Cent Hosp, Div Rehabil, Ikoma, Japan
[3] Hoshida Minami Hosp, Div Rehabil, Katano, Japan
来源：
PATHOBIOLOGY | 2017年 / 84卷 / 05期
关键词：
Fatty acid; Cancer stroma; Stromal stem cell; CANCER-CELLS; COLON-CANCER; PROSTATE-CANCER; LINOLEIC-ACID; METASTASIS; HEALTH; CONSUMPTION; INHIBITION; EXPRESSION; ADENOMAS;
D O I：
10.1159/000471854
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The potential effects of 2 types of fatty acids on colorectal cancer (CRC) were assessed using cancer stromal cells. Linoleic acid (LA; C-18, n-6 unsaturated fatty acid) and elaidic acid (EA; C-18, trans acid), both known to affect colon carcinogenesis and cancer progression, were administered by gavage to BALB/c mice, which were inoculated with CT26 syngeneic colon cancer cells in the back. Both EA and LA treatments enhanced tumor growth and metastasis. EA and LA also increased the number of CD133-positive stromal cells in the tumor capsule. Importantly, those cancer cells at the tumor periphery, physically attached to CD133-positive stromal cells, also expressed CD133. These findings suggest that EA and LA might induce stemness in cancer cells through physical association and promote cancer metastasis. (C) 2017 S. Karger AG, Basel
引用
收藏
页码：237 / 242
页数：6
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