A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver:: Inhibition of NF-κB?

被引：10
|
作者：
Axon, A. [1 ]
Cowie, D. E. [1 ]
Mann, D. A. [1 ]
Wright, M. C. [1 ]
机构：
[1] Newcastle Univ, Sch Med, Inst Cellular Med CALS, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
TOXICOLOGY | 2008年 / 246卷 / 01期
基金：
英国医学研究理事会;
关键词：
PXR; NF-kappa B; fibrosis; myofibroblast; apoptosis;
D O I：
10.1016/j.tox.2007.12.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The liver is susceptible to chronic damage through exposure to a variety of toxins (e.g. alcohol) and viruses (e.g. hepatitis Q. Obesity, autoimmune diseases (e.g. autoimmune hepatitis) and a variety of genetic diseases (e.g. Wilson's disease) also lead to chronic liver damage. This damage results in scarring fibrogenesis, structural disruption and functional impairment of the organ. Recent work suggests that there is cross-talk between the PXR and NF-kappa B pathways. This cross-talk may explain the observation that PXR activators inhibit liver fibrosis in in vitro and in vivo animal models of the disease. This reveiw will focus on the two transcription factors and their potential interaction. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：40 / 44
页数：5
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