Antibodies in the Treatment of Aplastic Anemia

被引：15

作者：

Gomez-Almaguer, David ^{[1
]}

Carlos Jaime-Perez, Jose ^{[1
]}

Ruiz-Arguelles, Guillermo J. ^{[2
]}

机构：

[1] Univ Hosp, Hematol Serv, UANL, Monterrey 64610, NL, Mexico

[2] Ctr Hematol & Med Interna Puebla, Puebla, Mexico

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2012年 / 60卷 / 02期

关键词：

Aplastic anemia; Antibodies; Alemtuzumab; Antithymocyte globulin; RABBIT ANTITHYMOCYTE GLOBULIN; ALEMTUZUMAB PLUS CYCLOSPORINE; COLONY-STIMULATING FACTOR; ANTI-THYMOCYTE GLOBULIN; IMMUNOSUPPRESSIVE THERAPY; ANTILYMPHOCYTE GLOBULIN; MARROW FAILURE; FOLLOW-UP; RITUXIMAB; CHILDREN;

D O I：

10.1007/s00005-012-0164-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibodies have been the cornerstone of treatment of acquired aplastic anemia for more than 25 years. Treatment with antithymocyte globulin (ATG) is considered pivotal and the addition of cyclosporine improves the overall response rate. This antibody is heterogeneous and horse ATG is apparently more effective than rabbit ATG. Several issues remain unsolved in relation to the combination of ATG and cyclosporine: cost, toxicity and late clonal disorders. In recent years, alternative immunosuppressive therapy has been proposed and new antibodies have emerged: porcine ATG, alemtuzumab, daclizumab, and rituximab. Experience with these antibodies is limited to a few studies with alemtuzumab being the most promising, but the results are interesting and provocative. More studies are needed to find the perfect antibody.

引用

页码：99 / 106

页数：8

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