CXCR4 Has a CXCL12-Independent Essential Role in MLL-AF9 Driven Acute Myeloid Leukemia

被引:0
|
作者
Ramakrishnan, Ramprasad [1 ]
Pena-Martinez, Pablo [1 ]
Agarwal, Puneet [2 ]
Hogberg, Carl [1 ]
Chapellier, Marion [1 ]
Shah, Mansi [2 ]
Nilsson, Bjorn [3 ]
Ebert, Benjamin L. [4 ]
Bhatia, Ravi [2 ]
Jaras, Marcus [1 ]
机构
[1] Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden
[2] Univ Alabama Birmingham, Div Hematol Oncol, Birmingham, AL 35294 USA
[3] Lund Univ, Div Hematol & Transfus Med, Lund, Sweden
[4] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA
关键词
D O I
10.1182/blood-2018-99-116137
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
774
引用
收藏
页数:2
相关论文
共 50 条
  • [41] MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
    K H M Prange
    A Mandoli
    T Kuznetsova
    S-Y Wang
    A M Sotoca
    A E Marneth
    B A van der Reijden
    H G Stunnenberg
    J H A Martens
    Oncogene, 2017, 36 : 3346 - 3356
  • [42] MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
    Prange, K. H. M.
    Mandoli, A.
    Kuznetsova, T.
    Wang, S-Y
    Sotoca, A. M.
    Marneth, A. E.
    van der Reijden, B. A.
    Stunnenberg, H. G.
    Martens, J. H. A.
    ONCOGENE, 2017, 36 (23) : 3346 - 3356
  • [43] Kruppel-like Factor 4 Supports the Expansion of Leukemia Stem Cells in MLL-AF9-driven Acute Myeloid Leukemia
    Lewis, Andrew Henry
    Bridges, Cory Seth
    Moorshead, David Neal
    Chen, Taylor J.
    Du, Wa
    Zorman, Barry
    Sumazin, Pavel
    Puppi, Monica
    Daniel Lacorazza, H.
    STEM CELLS, 2022, 40 (08) : 736 - 750
  • [44] Development and characterization of a DNA aptamer for MLL-AF9 expressing acute myeloid leukemia cells using whole cell-SELEX
    Kaylin G. Earnest
    Erin M. McConnell
    Eman M. Hassan
    Mark Wunderlich
    Bahareh Hosseinpour
    Bianca S. Bono
    Melissa J. Chee
    James C. Mulloy
    William G. Willmore
    Maria C. DeRosa
    Edward J. Merino
    Scientific Reports, 11
  • [45] Development and characterization of a DNA aptamer for MLL-AF9 expressing acute myeloid leukemia cells using whole cell-SELEX
    Earnest, Kaylin G.
    McConnell, Erin M.
    Hassan, Eman M.
    Wunderlich, Mark
    Hosseinpour, Bahareh
    Bono, Bianca S.
    Chee, Melissa J.
    Mulloy, James C.
    Willmore, William G.
    DeRosa, Maria C.
    Merino, Edward J.
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [46] STANDARD INDUCTION CHEMOTHERAPY IN CHILDREN WITH MLL-AF9 ACUTE MYELOID LEUKEMIA AND SEVERE DISSEMINATED INTRAVASCULAR COAGULATION IS ASSOCIATED WITH HIGH MORTALITY
    Colita, A.
    Asan, M.
    Gheorghe, A.
    Zaharia, C.
    Radu, L.
    Safta, M.
    Dragomir, M.
    Jardan, C.
    Colita, A.
    HAEMATOLOGICA, 2016, 101 : 681 - 682
  • [47] CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12
    Carvalho Melo, Rita de Cassia
    Longhini, Ana Leda
    Bigarella, Carolina Louzao
    Baratti, Mariana Ozello
    Traina, Fabiola
    Favaro, Patricia
    Campos, Paula de Melo
    Olalla Saad, Sara Teresinha
    PLOS ONE, 2014, 9 (01):
  • [48] Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target
    F Barabé
    L Gil
    M Celton
    A Bergeron
    V Lamontagne
    É Roques
    K Lagacé
    A Forest
    R Johnson
    L Pécheux
    J Simard
    J Pelloux
    A Bellemare-Pelletier
    E Gagnon
    J Hébert
    S Cellot
    B T Wilhelm
    Leukemia, 2017, 31 : 1166 - 1176
  • [49] Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target
    Barabe, F.
    Gil, L.
    Celton, M.
    Bergeron, A.
    Lamontagne, V.
    Roques, E.
    Lagace, K.
    Forest, A.
    Johnson, R.
    Pecheux, L.
    Simard, J.
    Pelloux, J.
    Bellemare-Pelletier, A.
    Gagnon, E.
    Hebert, J.
    Cellot, S.
    Wilhelm, B. T.
    LEUKEMIA, 2017, 31 (05) : 1166 - 1176
  • [50] Improving chemotherapeutic efficiency in acute myeloid leukemia treatments by chemically synthesized peptide interfering with CXCR4/CXCL12 axis
    Li, Xiaojin
    Guo, Hua
    Duan, Hongyang
    Yang, Yanlian
    Meng, Jie
    Liu, Jian
    Wang, Chen
    Xu, Haiyan
    SCIENTIFIC REPORTS, 2015, 5