Role of Cytokines, Chemokines and IFN-γ+ IL-17+ Double-Positive CD4+ T Cells in Patients with Multiple Sclerosis

被引：6

作者：

Dias de Sousa, Marlos Aureliano ^{[1
,2
]}

Desiderio, Chamberttan Souza ^{[1
]}

Catarino, Jonatas da Silva ^{[3
]}

Trevisan, Rafael Obata ^{[1
]}

Alves da Silva, Djalma Alexandre ^{[1
]}

Resende Rocha, Vinicius Ferreira ^{[1
]}

Bovi, Weslley Guimaraes ^{[1
]}

Timoteo, Rodolfo Pessato ^{[1
]}

Franzon Bonatti, Renata Cristina ^{[2
]}

da Silva, Alex Eduardo ^{[2
]}

Fernandez, Alfredo Leboreiro ^{[2
]}

Sales-Campos, Helioswilton ^{[4
]}

Rodrigues Junior, Virmondes ^{[1
]}

da Silva, Marcos Vinicius ^{[1
]}

Freire de Oliveira, Carlo Jose ^{[1
,5
]}

机构：

[1] Univ Fed Triangulo Mineiro, Dept Immunol Microbiol & Parasitol, BR-38025180 Uberaba, MG, Brazil

[2] Univ Fed Triangulo Mineiro, Dept Neurol, BR-38025180 Uberaba, MG, Brazil

[3] Yale Univ, Sch Med, Dept Comparat Med, Program Integrat Cell Signaling & Neurobiol Metab, New Haven, CT 06510 USA

[4] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, BR-74605050 Goiania, Go, Brazil

[5] Univ Fed Triangulo Mineiro, Lab Immunol & Bioinformat, Rua Vigario Carlos 100,8th Floor, BR-38025350 Uberaba, MG, Brazil

来源：

BIOMEDICINES | 2022年 / 10卷 / 09期

关键词：

Multiple sclerosis; cytokine; chemokine; double-positive CD4(+) T cells; CEREBROSPINAL-FLUID; INTERFERON-GAMMA; PROFILE; DYSREGULATION; EXPRESSION; DISEASE; IL-10; ALPHA; SERUM;

D O I：

10.3390/biomedicines10092062

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multiple sclerosis is mediated by self-reactive myelin T and B cells that lead to axonal and myelin damage. The immune response in multiple sclerosis involves the participation of CD4(+) T cells that produce cytokines and chemokines. This participation is important to find markers for the diagnosis and progression of the disease. In our work, we evaluated the profile of cytokines and chemokines, as well as the production of double positive CD4(+) T cells for the production of IFN gamma IL-17 in patients with multiple sclerosis, at different stages of the disease and undergoing different treatments. We found that relapsing-remitting patients had a significant increase in IL-12 production. About IL-5, its production showed significantly higher levels in secondarily progressive patients when compared to relapsing-remitting patients. IFN-gamma production by PBMCs from secondarily progressive patients showed significantly higher levels. This group also had a higher percentage of CD4(+)IFN gamma(+) IL-17(+) T cells. The combination of changes in certain cytokines and chemokines together with the presence of IFN gamma(+) IL-17(+) double positive lymphocytes can be used to better understand the clinical forms of the disease and its progression.

引用

页数：14

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