LKB1/PAR4 protein is asymmetrically localized in mouse oocytes and associates with meiotic spindle

被引：19

作者：

Szczepanska, K ^{[1
]}

Maleszewski, M ^{[1
]}

机构：

[1] Warsaw Univ, Inst Zool, Dept Embryol, PL-02096 Warsaw, Poland

来源：

GENE EXPRESSION PATTERNS | 2005年 / 6卷 / 01期

关键词：

mouse; oocyte; meiosis; polarization; spindle; microtubules; PAR4; LKB1;

D O I：

10.1016/j.modgep.2005.04.013

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mouse secondary oocyte is polarized at the ultrastructural and molecular level, but very little is known about mechanisms involved in the establishment of this polarity. We showed that the LKB1 kinase, a mouse homologue of Caenorhabditis elegans PAR4 protein is asymmetrically localized to the animal pole of the mouse oocyte and during oocyte maturation associates with the microtubules of metaphase I and metaphase II meiotic spindles. Therefore, we suggest that LKB1/PAR4 protein, may participate in the polarization of the oocyte and in the regulation of the asymmetry of meiotic divisions during mouse oogenesis. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：86 / 93

页数：8

共 48 条

[41] Insights into the structural dynamics of Liver kinase B1 (LKB1) by the binding of STe20 Related Adapter (STRAD) and Mouse protein 25 (MO25) co-activators
Rungsung, Ikrormi
Ramaswamy, Amutha
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2017, 35 (05): : 1138 - 1152
[42] Septin 4 controls CCNB1 stabilization via APC/CCDC20 during meiotic G2/M transition in mouse oocytes
Chen, Li
Ouyang, Ying-Chun
Li, Jian
Qiao, Jing-Yi
Gu, Lin -Jian
Wang, Zhen-Bo
Hou, Yi
Schatten, Heide
Sun, Qing-Yuan
JOURNAL OF CELLULAR PHYSIOLOGY, 2022, 237 (01) : 730 - 742
[43] Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against hypoxia-reperfusion injury in vitro by activating liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling
Zheng, Yu
Tao, Yingying
Zhan, Xiaobo
Wu, Qi
BIOENGINEERED, 2022, 13 (04) : 8349 - 8359
[44] Two chalcones, 4-hydroxyderricin and xanthoangelol, stimulate GLUT4-dependent glucose uptake through the LKB1/AMP-activated protein kinase signaling pathway in 3T3-L1 adipocytes
Ohta, Mitsuhiro
Fujinami, Aya
Kobayashi, Norihiro
Amano, Akiko
Ishigami, Akihito
Tokuda, Harukuni
Suzuki, Nobutaka
Ito, Fumitake
Mori, Taisuke
Sawada, Morio
Iwasa, Koichi
Kitawaki, Jo
Ohnishi, Katsunori
Tsujikawa, Muneo
Obayashi, Hiroshi
NUTRITION RESEARCH, 2015, 35 (07) : 618 - 625
[45] Unique subcellular distribution of phosphorylated Plk1 (Ser137 and Thr210) in mouse oocytes during meiotic division and pPlk1Ser137 involvement in spindle formation and REC8 cleavage
Du, Juan
Cao, Yan
Wang, Qian
Zhang, Nana
Liu, Xiaoyu
Chen, Dandan
Liu, Xiaoyun
Xu, Qunyuan
Ma, Wei
CELL CYCLE, 2015, 14 (22) : 3566 - 3579
[46] Ribosomal S6 kinase p90(rsk) and mRNA cap-binding protein eIF4E phosphorylations correlate with MAP kinase activation during meiotic reinitiation of mouse oocytes
Gavin, AC
SchorderetSlatkine, S
MOLECULAR REPRODUCTION AND DEVELOPMENT, 1997, 46 (03) : 383 - 391
[47] Interaction of Nuclear Receptor Subfamily 4 Group A Member 1 (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-κB) Activation
Ming, Yi
Yin, Youmin
Sun, Zhaoli
MEDICAL SCIENCE MONITOR, 2020, 26
[48] Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11 - Cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translation
Wagner, TM
Mullally, JE
Fitzpatrick, FA
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (05) : 2598 - 2604

← 1 2 3 4 5 →