Losing a child at the beginning of life is one of the most intense emotional stressors that may experience a woman. The evaluation of this mourning process requires reliable and valid instruments. This study aimed to determine the psychometric characteristics of the Perinatal Grief Scale (PGS) in a sample of Mexican women who had experienced perinatal loss. The scale was translated, retranslated, tested and adapted to finally be applied to 200 women who had experienced one or more perinatal loss and were attending a clinic. Data were subjected to the usual statistical procedures of validation (analysis of frequency distribution, comparison of extreme groups, exploratory factor analysis and factor analysis confirming, as well as correlation between scales) and evaluation of internal consistency, obtaining appropriate indexes of reliability and validity. The Perinatal Grief Scale (EDP) was formed by 27 items, grouped in four scales: active grief, depression, guilt, and acceptance. Its use in research and clinical practice is discussed.