共 50 条
- [21] Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2000, 56 : 294 - 303Krishnan, RMochalkin, IArni, RTulinsky, A
- [22] P1′ modified sultam hydroxamates as potent MMP inhibitorsABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U2666 - U2666Mo, RWMeyer, DTWasserman, ZRHardman, KDLiu, RQCovington, MBQian, MXChrist, DDTrzaskos, JMNewton, RCDecicco, CPCherney, RJ
- [23] THE DEVELOPMENT OF POTENT AND HIGHLY SELECTIVE THROMBIN INHIBITORSEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1995, 30 : S131 - S138HILPERT, KACKERMANN, JBANNER, DWGAST, AGUBERNATOR, KSCHMID, GTSCHOPP, TBVANDEWATERBEEMD, K
- [24] The discovery of orally available thrombin inhibitors: Optimisation of the P1 pharmacophoreBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (08) : 1103 - 1108Ambler, JBentley, DBrown, LDunnet, KFarr, DJanus, DLe Grand, DMenear, KMercer, MTalbot, MTweed, MWathey, B
- [25] Boro-norleucine as a P1 residue for the design of selective and potent DPP7 inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (19) : 4256 - 4260Shreder, KRWong, MSCorral, SYu, ZZWinn, DTWu, MHu, YNomanbhoy, TAlemayehu, SFuller, SRRosenblum, JSKozarich, JW
- [26] Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 positionJOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (17) : 3210 - 3219Tucker, TJBrady, SFLumma, WCLewis, SDGardell, SJNaylor-Olsen, AMYan, YWSisko, JTStauffer, KJLucas, BJLynch, JJCook, JJStranieri, MTHolahan, MALyle, EABaskin, EPChen, IWDancheck, KBKrueger, JACooper, CMVacca, JP
- [27] CHARACTERIZATION OF A CLASS OF PEPTIDE BORONATES WITH NEUTRAL P1 SIDE-CHAINS AS HIGHLY SELECTIVE INHIBITORS OF THROMBINJOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (09) : 1511 - 1522DEADMAN, JJELGENDY, SGOODWIN, CAGREEN, DBABAN, JAPATEL, GSKORDALAKES, ECHINO, NCLAESON, GKAKKAR, VVSCULLY, MF
- [28] Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 positionJOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (23) : 3726 - 3733Feng, DMGardell, SJLewis, SDBock, MGChen, ZGFreidinger, RMNaylorOlsen, AMRamjit, HGWoltmann, RBaskin, EPLynch, JJLucas, RShafer, JADancheck, KBChen, IWMao, SSKrueger, JAHare, TRMulichak, AMVacca, JP
- [29] Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 positionPEPTIDES: FRONTIERS OF PEPTIDES SCIENCE, 1999, : 672 - 673Feng, DMFreidinger, RMLevis, SDGardell, SJBock, MGChen, ZGNaylor-Olsen, AWoltmann, RBaskin, EPLynch, JJLucas, RShafer, JADancheck, KBChen, IWVacca, JP
- [30] Novel, potent non-covalent thrombin inhibitors incorporating P3-lactam scaffoldsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (05) : 743 - 748Ho, JZGibson, TSSemple, JE