Morphometry of the amygdala in schizophrenia and psychotic bipolar disorder

被引：20
|
作者：
Mahon, Pamela B. [1 ,2 ]
Lee, David S. [3 ]
Trinh, Huong [3 ]
Tward, Daniel [3 ]
Miller, Michael I. [3 ,4 ,5 ]
Younes, Laurent [3 ,5 ,6 ]
Barta, Patrick E. [3 ,4 ,5 ]
Ratnanather, J. Tilak [3 ,4 ,5 ]
机构：
[1] Johns Hopkins Sch Med, Mood Disorders Ctr, Baltimore, MD 21287 USA
[2] Johns Hopkins Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Ctr Imaging Sci, Baltimore, MD USA
[4] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA
[5] Johns Hopkins Univ, Inst Computat Med, Baltimore, MD USA
[6] Johns Hopkins Univ, Dept Appl Math & Stat, Baltimore, MD USA
来源：
SCHIZOPHRENIA RESEARCH | 2015年 / 164卷 / 1-3期
关键词：
Psychotic bipolar disorder; Schizophrenia; Amygdala; Morphometry; QUANTITATIVE METAANALYSIS; HIPPOCAMPAL; VOLUMES; EMOTION; ATROPHY; SHAPE;
D O I：
10.1016/j.schres.2015.02.011
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Volumetric studies suggest smaller amygdalae in subjects with schizophrenia (SZ) than with bipolar disorder (BP). We use morphometry to identify subregions of amygdala differentially affected in SZ and psychotic BP. Based on template centered population analysis, the shape of the amygdala in psychotic BP differs from SZ (p(left) = 0.044, p(right) = 0.042). Using a high-field 7 T atlas, the bilateral basolateral, basomedial and centromedial subregions and the right lateral subregion were significantly atrophied in SZ compared to psychotic BP (p < 0.02). These results suggest that change in shape of amygdala may represent a morphologic feature distinguishing SZ from psychotic BP. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：199 / 202
页数：4
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