Safety and Efficacy of Intravenous Colistin in Children

被引：13
|
作者：
Kumar, Poddutoor Preetham [1 ]
Giri, Swapnil Rameshwar [1 ]
Shaikh, Farhan A. R. [1 ]
Panigrahy, Nalinikant [1 ]
Cherla, Dinesh [1 ]
机构：
[1] Rainbow Childrens Hosp, Dept Intens Care, Hyderabad 500034, Andhra Pradesh, India
来源：
INDIAN PEDIATRICS | 2015年 / 52卷 / 02期
关键词：
Acute kidney injury; Antimicrobial resistance; Colistin; MULTIDRUG-RESISTANT;
D O I：
10.1007/s13312-015-0586-1
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Objective: To observe the safety and efficacy of Colistimethate sodium in children infected with gram-negative bacteria, susceptible only to colistimethate sodium. Methods: This prospective observational study done over 2 years observed children who received colistin for >48 h, for renal failure as defined by p-RIFLE criteria. Results: Out of 68 children, 52 (76.5%) survived. There were three children with evidence of acute kidney injury and none had neurotoxicity. Serum creatinine significantly decreased at 48 h and at end of treatment, from that at beginning of therapy (P=0.007). Conclusion: Colistimethate sodium is effective against carbapenem-resistant Gram-negative bacteria, and is safe in children.
引用
收藏
页码：129 / 130
页数：2
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