Simple microwave-assisted ligand-free Suzuki cross-coupling: Functionalization of halo-pyrimidine moieties

被引：18
|
作者：
Colombo, Matteo [1 ]
Giglio, Marco [1 ]
Peretto, Ilaria [1 ]
机构：
[1] NiKem Res, I-20021 Milan, Italy
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2008年 / 45卷 / 04期
关键词：
D O I：
10.1002/jhet.5570450420
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An advantageous ligand-free protocol for Suzuki couplings is described. The synthetic procedure entails microwave irradiation for the reduction of the reaction times and the use of silica cartridges for the purification. Dihalo-pyrimidine structures, interesting scaffolds in medicinal chemistry, were chosen as test compounds.
引用
收藏
页码：1077 / 1081
页数：5
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