Microwave-assisted Suzuki-Miyaura Cross-Coupling of Free (NH) 3-Bromoindazoles

被引：10
|
作者：
Ben-Yahia, Ali [1 ,2 ,4 ]
Naas, Mohammed [2 ,4 ]
El Brahmi, Nabil [1 ,2 ,3 ]
El Kazzouli, Said [1 ]
Majoral, Jean-Pierre [3 ]
Essassi, El Mokhtar [1 ,2 ]
Guillaumet, Gerald [4 ]
机构：
[1] MAScIR Fdn, Inst Nanomat & Nanotechnol INANOTECH, Rabat 10100, Morocco
[2] Univ Mohammed V Agdal, Lab Chim Organ Heterocycl URAC 21, Rabat, Morocco
[3] CNRS, Lab Chim Coordinat, F-31077 Toulouse 4, France
[4] Univ Orleans, Inst Chim Organ & Analyt, UMR CNRS 7311, F-45067 Orleans 2, France
来源：
CURRENT ORGANIC CHEMISTRY | 2013年 / 17卷 / 03期
关键词：
Suzuki-Miyaura cross-coupling; Free (NH) indazoles; Microwave irradiation; Palladium-mediated cross-coupling; Boronic acids; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; BORONIC ACIDS; INDAZOLE; DESIGN; INHIBITORS; 3-IODOINDAZOLES; DERIVATIVES; STRATEGY; POTENCY;
D O I：
10.2174/1385272811317030011
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Suzuki-Miyaura cross-coupling of free (NH) indazoles is described. The reactions are carried out under microwave irradiation using various 3-bromoindazoles and boronic acids. Different reaction conditions were investigated and the best results were obtained using Pd(PPh3)(4) and Cs2CO3 in a mixture of 1,4-dioxane/EtOH/H2O at 140 degrees C under microwave irradiation.
引用
收藏
页码：304 / 309
页数：6
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