Synthesis of a PNA-peptide conjugate by chemical ligation

被引：0
|
作者：
de Koning, MC [1 ]
Filippov, DV [1 ]
Meeuwenoord, N [1 ]
Overhand, M [1 ]
van der Marel, GA [1 ]
van Boom, JH [1 ]
机构：
[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands
来源：
SYNLETT | 2001年 / 10期
关键词：
native chemical ligation; PNA-peptide conjugate; nuclear localization signal; convergent synthesis;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convergent synthetic route to the construction of a PNA-N-to-C-peptide conjugate (PKKKRKVGC-ttgcatt) by regioselective condensation of a thioester peptide and a cysteine-PNA adduct under denaturating conditions is described.
引用
收藏
页码：1516 / 1518
页数：3
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