Differential expression of the murine Ly-6A/E antigen homolog of human squamous cell carcinoma antigen E48 during malignant transformation and tumor progression of squamous cell carcinoma line Pam 212

被引：5

作者：

Kato, T ^{[1
]}

Dong, G ^{[1
]}

Loukinova, E ^{[1
]}

Chen, Z ^{[1
]}

Van Waes, C ^{[1
]}

机构：

[1] Natl Inst Deafness & Other Commun Disorders, Tumor Biol Sect, Head & Neck Surg Branch, NIH, Bethesda, MD 20892 USA

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 1998年 / 119卷 / 04期

关键词：

D O I：

10.1016/S0194-5998(98)70091-9

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The mRNA differential display method detected increased expression of the mRNA of an immune recognition antigen known as Ly-6A/E after malignant transformation of the murine squamous cell carcinoma line Pam 212, Subsequent loss of expression of Ly-6A/E occurred with metastatic tumor progression of Pam in vivo. Ly-6 molecules have been implicated in immune cell recognition and signal transduction and are homologous to the human E48 SCC antigen that has been shown to be involved in cell-cell recognition. These observations suggest that loss of Ly-6A/E antigen may contribute to tumor progression and metastasis of squamous cell carcinoma through decreased tumor-lymphocyte or tumor-tumor recognition.

引用

页码：408 / 411

页数：4

共 42 条

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