Differential expression of the murine Ly-6A/E antigen homolog of human squamous cell carcinoma antigen E48 during malignant transformation and tumor progression of squamous cell carcinoma line Pam 212

被引：5
|
作者：
Kato, T [1 ]
Dong, G [1 ]
Loukinova, E [1 ]
Chen, Z [1 ]
Van Waes, C [1 ]
机构：
[1] Natl Inst Deafness & Other Commun Disorders, Tumor Biol Sect, Head & Neck Surg Branch, NIH, Bethesda, MD 20892 USA
来源：
OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 1998年 / 119卷 / 04期
关键词：
D O I：
10.1016/S0194-5998(98)70091-9
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The mRNA differential display method detected increased expression of the mRNA of an immune recognition antigen known as Ly-6A/E after malignant transformation of the murine squamous cell carcinoma line Pam 212, Subsequent loss of expression of Ly-6A/E occurred with metastatic tumor progression of Pam in vivo. Ly-6 molecules have been implicated in immune cell recognition and signal transduction and are homologous to the human E48 SCC antigen that has been shown to be involved in cell-cell recognition. These observations suggest that loss of Ly-6A/E antigen may contribute to tumor progression and metastasis of squamous cell carcinoma through decreased tumor-lymphocyte or tumor-tumor recognition.
引用
收藏
页码：408 / 411
页数：4
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