The role of vascular endothelial growth factor in osteoarthritis: a review

被引：0

作者：

Song, Jia Lin ^{[1
]}

Wang, Yi Ting ^{[2
]}

Ouyang, Jia Yao ^{[1
]}

Li, De Long ^{[1
]}

Xie, Deng Hui ^{[1
]}

Zhang, Hai Yan ^{[1
]}

Fang, Hang ^{[1
]}

Cai, Dao Zhang ^{[1
]}

机构：

[1] Southern Med Univ, Affiliated Hosp 3, Dept Orthoped, 183 West Zhongshan Ave, Guangzhou 510630, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Clin Pharmacol, 26 Yuancun Erheng Rd, Guangzhou 510655, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2019年 / 12卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Vascular endothelial growth factor; osteoarthritis; articular cartilage; subchondral bone; OSTEOCLASTIC BONE-RESORPTION; FACTOR VEGF; SYNOVIAL-FLUID; RHEUMATOID-ARTHRITIS; OSTEOPHYTE FORMATION; SUBCHONDRAL BONE; TROPONIN-I; EXPRESSION; CARTILAGE; ANGIOGENESIS;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Osteoarthritis (OA) is the most prevalent form of joint disease, with a high prevalence in the elderly. Its primary clinical symptoms are joint pain and restricted movement, with main pathologies of synovitis, cartilage degeneration, subchondral bone sclerosis, and osteophyte formation. Vascular endothelial growth factor (VEGF) is expressed in articular cartilage and increases in expression levels have been associated with progression of OA. Moreover, VEGF has been found to play an important role in the pathogenesis of OA of synovitis, cartilage degeneration, subchondral bone sclerosis, and osteophyte formation. The aim of this article was to examine the role of VEGF in OA and related studies.

引用

页码：194 / 200

页数：7

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