ORFanFinder: automated identification of taxonomically restricted orphan genes

被引:10
|
作者
Ekstrom, Alex [1 ]
Yin, Yanbin [2 ]
机构
[1] Northern Illinois Univ, Dept Comp Sci, De Kalb, IL 60115 USA
[2] Northern Illinois Univ, Dept Biol Sci, Montgomery Hall 325A, De Kalb, IL 60115 USA
基金
美国国家卫生研究院;
关键词
ORFANS; ORIGIN;
D O I
10.1093/bioinformatics/btw122
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Motivation: Orphan genes, also known as ORFans, are newly evolved genes in a genome that enable the organism to adapt to specific living environment. The gene content of every sequenced genome can be classified into different age groups, based on how widely/narrowly a gene's homo-logs are distributed in the context of species taxonomy. Those having homologs restricted to organisms of particular taxonomic ranks are classified as taxonomically restricted ORFans. Results: Implementing this idea, we have developed an open source program named ORFanFinder and a free web server to allow automated classification of a genome's gene content and identification of ORFans at different taxonomic ranks. ORFanFinder and its web server will contribute to the comparative genomics field by facilitating the study of the origin of new genes and the emergence of lineage-specific traits in both prokaryotes and eukaryotes.
引用
收藏
页码:2053 / 2055
页数:3
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