MicroRNA regulation of airway smooth muscle function

被引：11

作者：

Sun, Maoyun ^{[1
,2
,3
]}

Lu, Quan ^{[1
,2
,3
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Program Mol & Integrat Physiol Sci, Dept Environm Hlth, 665 Huntington Ave, Boston, MA 02115 USA

[2] Harvard TH Chan Sch Publ Hlth, Dept Genet, 665 Huntington Ave, Boston, MA 02115 USA

[3] Harvard TH Chan Sch Publ Hlth, Dept Complex Dis, 665 Huntington Ave, Boston, MA 02115 USA

来源：

BIOLOGICAL CHEMISTRY | 2016年 / 397卷 / 06期

关键词：

airway hyperresponsiveness (AHR); ASM mass; asthmatic; inflammation; PI3K; pulmonary; IN-VIVO; CELL-PROLIFERATION; TUMOR-SUPPRESSOR; SEVERE ASTHMA; EXPRESSION; HYPERTROPHY; INFLAMMATION; GROWTH; KRUPPEL-LIKE-FACTOR-4; HYPERRESPONSIVENESS;

D O I：

10.1515/hsz-2015-0298

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Airway smooth muscle (ASM) controls airway narrowing and plays a pivotal role in the pathogenesis of asthma. MicroRNAs are small yet powerful gene tuners that regulate diverse cellular processes. Recent studies have demonstrated the versatile role of microRNAs in regulating multiple ASM phenotypes that are critically involved in asthma pathogenesis. These ASM phenotypes include proliferation, cell size, chemokine secretion, and contractility. Here we review microRNA-mediated regulation of ASM functions and discuss the potential of - microRNAs as a novel class of therapeutic targets to improve ASM function for asthma therapy.

引用

页码：507 / 511

页数：5

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