Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers

被引：15

作者：

Dennis, Jessica ^{[3
,4
]}

Ghadirian, Parviz ^{[4
,5
]}

Little, Julian ^{[3
,4
]}

Lubinski, Jan ^{[6
]}

Gronwald, Jacek ^{[6
]}

Kim-Sing, Charmaine ^{[7
]}

Foulkes, William ^{[8
,9
]}

Moller, Pal ^{[10
]}

Lynch, Henry T. ^{[11
]}

Neuhausen, Susan L. ^{[12
]}

Domchek, Susan ^{[13
]}

Armel, Susan ^{[14
]}

Isaacs, Claudine ^{[15
]}

Tung, Nadine ^{[16
]}

Sweet, Kevin ^{[17
]}

Ainsworth, Peter ^{[18
]}

Sun, Ping ^{[2
]}

Krewski, Daniel ^{[3
,4
]}

Narod, Steven ^{[1
,2
]}

机构：

[1] Womens Coll Hosp, Womens Coll Res Inst, Toronto, ON M5G 1N8, Canada

[2] Univ Toronto, Toronto, ON M5S 1A1, Canada

[3] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON, Canada

[4] Univ Ottawa, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada

[5] CHUM Hotel Dieu, CHU Montreal, Montreal, PQ, Canada

[6] Pomeranian Med Univ, Hereditary Canc Ctr, Szczecin, Poland

[7] BC Canc Agcy, Vancouver, BC, Canada

[8] McGill Univ, Dept Med Genet, Montreal, PQ H3A 2T5, Canada

[9] McGill Univ, Dept Oncol, Montreal, PQ H3A 2T5, Canada

[10] Univ Oslo, Natl Hosp, Dept Med Genet, Sect Canc Genet, Oslo, Norway

[11] Creighton Univ, Sch Med, Dept Prevent Med & Publ Hlth, Omaha, NE USA

[12] Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA

[13] Univ Penn, Abramson Canc Ctr, Sch Med, Philadelphia, PA 19104 USA

[14] Univ Hlth Network, Dept Obstet & Gynecol, Toronto, ON, Canada

[15] Georgetown Univ, Med Ctr Georgetown, Lombardi Canc Ctr, Washington, DC USA

[16] Beth Israel Deaconess Med Ctr, Ma, OH USA

[17] Ohio State Med Ctr, Div Med Genet, Columbus, OH USA

[18] London Reg Canc Program, London, ON, Canada

来源：

BREAST | 2010年 / 19卷 / 06期

关键词：

BRCA1; BRCA2; Alcohol; Breast cancer; Case-control; Wine; POSTMENOPAUSAL WOMEN; WINE CONSUMPTION; CELL-LINES; RESVERATROL; PREMENOPAUSAL; EXPRESSION; NUTRITION; AGE;

D O I：

10.1016/j.breast.2010.05.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% Cl 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00: 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRA gene mutation. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：479 / 483

页数：5

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