Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers

被引：15

作者：

Dennis, Jessica ^{[3
,4
]}

Ghadirian, Parviz ^{[4
,5
]}

Little, Julian ^{[3
,4
]}

Lubinski, Jan ^{[6
]}

Gronwald, Jacek ^{[6
]}

Kim-Sing, Charmaine ^{[7
]}

Foulkes, William ^{[8
,9
]}

Moller, Pal ^{[10
]}

Lynch, Henry T. ^{[11
]}

Neuhausen, Susan L. ^{[12
]}

Domchek, Susan ^{[13
]}

Armel, Susan ^{[14
]}

Isaacs, Claudine ^{[15
]}

Tung, Nadine ^{[16
]}

Sweet, Kevin ^{[17
]}

Ainsworth, Peter ^{[18
]}

Sun, Ping ^{[2
]}

Krewski, Daniel ^{[3
,4
]}

Narod, Steven ^{[1
,2
]}

机构：

[1] Womens Coll Hosp, Womens Coll Res Inst, Toronto, ON M5G 1N8, Canada

[2] Univ Toronto, Toronto, ON M5S 1A1, Canada

[3] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON, Canada

[4] Univ Ottawa, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada

[5] CHUM Hotel Dieu, CHU Montreal, Montreal, PQ, Canada

[6] Pomeranian Med Univ, Hereditary Canc Ctr, Szczecin, Poland

[7] BC Canc Agcy, Vancouver, BC, Canada

[8] McGill Univ, Dept Med Genet, Montreal, PQ H3A 2T5, Canada

[9] McGill Univ, Dept Oncol, Montreal, PQ H3A 2T5, Canada

[10] Univ Oslo, Natl Hosp, Dept Med Genet, Sect Canc Genet, Oslo, Norway

[11] Creighton Univ, Sch Med, Dept Prevent Med & Publ Hlth, Omaha, NE USA

[12] Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA

[13] Univ Penn, Abramson Canc Ctr, Sch Med, Philadelphia, PA 19104 USA

[14] Univ Hlth Network, Dept Obstet & Gynecol, Toronto, ON, Canada

[15] Georgetown Univ, Med Ctr Georgetown, Lombardi Canc Ctr, Washington, DC USA

[16] Beth Israel Deaconess Med Ctr, Ma, OH USA

[17] Ohio State Med Ctr, Div Med Genet, Columbus, OH USA

[18] London Reg Canc Program, London, ON, Canada

来源：

BREAST | 2010年 / 19卷 / 06期

关键词：

BRCA1; BRCA2; Alcohol; Breast cancer; Case-control; Wine; POSTMENOPAUSAL WOMEN; WINE CONSUMPTION; CELL-LINES; RESVERATROL; PREMENOPAUSAL; EXPRESSION; NUTRITION; AGE;

D O I：

10.1016/j.breast.2010.05.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% Cl 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00: 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRA gene mutation. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：479 / 483

页数：5

共 50 条

[1] Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers
Nkondjock, A
Ghadirian, P
Kotsopoulos, J
Lubinski, J
Lynch, H
Kim-Sing, C
Horsman, D
Rosen, B
Isaacs, C
Weber, B
Foulkes, W
Ainsworth, P
Tung, N
Eisen, A
Friedman, E
Eng, C
Sun, P
Narod, SA
INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (01) : 103 - 107
[2] Prospective evaluation of alcohol consumption and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
Cybulski, Cezary
Lubinski, Jan
Huzarski, Tomasz
Lynch, Henry T.
Randall, Susan Armel
Neuhausen, Susan L.
Senter, Leigha
Friedman, Susan
Ainsworth, Peter
Singer, Christian
Foulkes, William D.
Narod, Steven A.
Sun, Ping
Kotsopoulos, Joanne
BREAST CANCER RESEARCH AND TREATMENT, 2015, 151 (02) : 435 - 441
[3] Prospective evaluation of alcohol consumption and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
Cezary Cybulski
Jan Lubinski
Tomasz Huzarski
Henry T. Lynch
Susan Armel Randall
Susan L. Neuhausen
Leigha Senter
Susan Friedman
Peter Ainsworth
Christian Singer
William D. Foulkes
Steven A. Narod
Ping Sun
Joanne Kotsopoulos
Breast Cancer Research and Treatment, 2015, 151 : 435 - 441
[4] Breast cancer risk among male BRCA1 and BRCA2 mutation carriers
Tai, Yu Chuan
Domchek, Susan
Parmigiani, Giovanni
Chen, Sining
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (23) : 1811 - 1814
[5] Parity and breast cancer risk among BRCA1 and BRCA2 mutation carriers
Antoniou, Antonis C.
Shenton, Andrew
Maher, Eamonn R.
Watson, Emma
Woodward, Emma
Lalloo, Fiona
Easton, Douglas F.
Evans, D. Gareth
BREAST CANCER RESEARCH, 2006, 8 (06)
[6] Alcohol Consumption, Cigarette Smoking, and Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Results from The BRCA1 and BRCA2 Cohort Consortium
Li, Hongyan
Terry, Mary Beth
Antoniou, Antonis C.
Phillips, Kelly-Anne
Kast, Karin
Mooij, Thea M.
Engel, Christoph
Nogues, Catherine
Stoppa-Lyonnet, Dominique
Lasset, Christine
Berthet, Pascaline
Mari, Veronique
Caron, Olivier
Barrowdale, Daniel
Frost, Debra
Brewer, Carole
Evans, D. Gareth
Izatt, Louise
Side, Lucy
Walker, Lisa
Tischkowitz, Marc
Rogers, Mark T.
Porteous, Mary E.
Snape, Katie
Meijers-Heijboer, Hanne E. J.
Gille, Johan J. P.
Blok, Marinus J.
Hoogerbrugge, Nicoline
Daly, Mary B.
Andrulis, Irene L.
Buys, Saundra S.
John, Esther M.
McLachlan, Sue-Anne
Friedlander, Michael
Tan, Yen Y.
Osorio, Ana
Caldes, Trinidad
Jakubowska, Anna
Simard, Jacques
Singer, Christian F.
Olah, Edith
Navratilova, Marie
Foretova, Lenka
Gerdes, Anne-Marie
Roos-Blom, Marie-Jose
Arver, Brita
Olsson, Hakan
Schmutzler, Rita K.
Hopper, John L.
Milne, Roger L.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2020, 29 (02) : 368 - 378
[7] Aspirin and breast cancer risk for BRCA1 and BRCA2 mutation carriers
Kornhauser, Naomi
Terry, Mary Beth
Vahdat, Linda T.
Andrulis, Irene
Buys, Saundra
Daly, Mary
John, Esther
Hopper, John L.
Cigler, Tessa
CANCER RESEARCH, 2015, 75
[8] Risk of ipsilateral breast cancer in BRCA1 and BRCA2 mutation carriers
Kelly Metcalfe
Henry T. Lynch
Parviz Ghadirian
Nadine Tung
Charmaine Kim-Sing
Olufunmilayo I. Olopade
Susan Domchek
Andrea Eisen
William D. Foulkes
Barry Rosen
Danny Vesprini
Ping Sun
Steven A. Narod
Breast Cancer Research and Treatment, 2011, 127 : 287 - 296
[9] Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
Joanne Kotsopoulos
Jan Lubinski
Leonardo Salmena
Henry T Lynch
Charmaine Kim-Sing
William D Foulkes
Parviz Ghadirian
Susan L Neuhausen
Rochelle Demsky
Nadine Tung
Peter Ainsworth
Leigha Senter
Andrea Eisen
Charis Eng
Christian Singer
Ophira Ginsburg
Joanne Blum
Tomasz Huzarski
Aletta Poll
Ping Sun
Steven A Narod
Breast Cancer Research, 14
[10] Variation in breast cancer risk in BRCA1 and BRCA2 mutation carriers
Timothy R Rebbeck
Susan M Domchek
Breast Cancer Research, 10

← 1 2 3 4 5 →