Family clustering of Baeyer-Villiger monooxygenases based on protein sequence and stereopreference

被引：60
|
作者：
Mihovilovic, MD
Rudroff, F
Grötzl, B
Kapitan, P
Snajdrova, R
Rydz, J
Mach, R
机构：
[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria
[2] Vienna Univ Technol, Inst Chem Engn, Vienna, Austria
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 23期
关键词：
biocatalysis; bioorganic chemistry; monooxygenases; oxidation; phylogenetic analysis;
D O I：
10.1002/anie.200462964
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) The identification of enzyme pairs with overlapping substrate specificity and enantiocomplementary transformations is a key challenge in biocatalysis. Enantio and regiodivergent Baeyer-Villiger oxidations were successfully carried out by using a small library of recombinant Escherichia coli strains expressing monooxygenases of various microbial origin (see picture). The clustering of enzymes based on stereopreference is in good agreement with phylogenetic similarity. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3609 / 3613
页数：5
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