Autism spectrum disorder: An omics perspective

被引：7

作者：

Woods, Alisa G. ^{[1
,2
,3
]}

Wormwood, Kelly L. ^{[1
]}

Wetie, Armand G. Ngounou ^{[1
]}

Aslebagh, Roshanak ^{[1
]}

Crimmins, Bernard S. ^{[2
,3
]}

Holsen, Thomas M. ^{[4
]}

Darie, Costel C. ^{[1
]}

机构：

[1] Clarkson Univ, Dept Chem & Biomol Sci, Biochem & Prote Grp, Potsdam, NY 13699 USA

[2] SUNY Coll Plattsburgh, Neuropsychol Clin, Plattsburgh, NY 12901 USA

[3] SUNY Coll Plattsburgh, Psychoeduc Serv, Plattsburgh, NY 12901 USA

[4] Clarkson Univ, Dept Civil & Environm Engn, Potsdam, NY USA

来源：

PROTEOMICS CLINICAL APPLICATIONS | 2015年 / 9卷 / 1-2期

关键词：

Autism spectrum disorder; Neurodevlopmental disorders; FRAGILE-X-SYNDROME; PROTEIN-PROTEIN INTERACTIONS; LEMLI-OPITZ-SYNDROME; INTRON; METHYLATION; MASS-SPECTROMETRY; GEL-ELECTROPHORESIS; MENTAL-RETARDATION; PROTEOMIC ANALYSIS; BEHAVIORAL-PHENOTYPE; FLAME RETARDANTS;

D O I：

10.1002/prca.201400116

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Current directions in autism spectrum disorder (ASD) research may require moving beyond genetic analysis alone, based on the complexity of the disorder, heterogeneity and convergence of genetic alterations at the cellular/functional level. Mass spectrometry (MS) has been increasingly used to study CNS disorders, including ASDs. Proteomic research using MS is directed at understanding endogenous protein changes that occur in ASD. This review focuses on how MS has been used to study ASDs, with particular focus on proteomic analysis. Other neurodevelopmental disorders have been investigated using MS, including fragile X syndrome (FXS) and Smith-Lemli-Opitz Syndrome (SLOS), genetic syndromes highly associated with ASD comorbidity.

引用

页码：159 / 168

页数：10

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