The use of intravenous immunoglobulin in sine causa or alloimmune recurrent spontaneous abortion (RSA)

被引:0
|
作者
Patriarca, A [1 ]
Piccioni, V [1 ]
Gigante, V [1 ]
Benedetto, C [1 ]
机构
[1] Univ Turin, Dipartimento Sci Ginecol & Ostetriche, Chair C, Turin, Italy
关键词
immunotherapy; idiopathic recurrent spontaneous abortion abortion; habitual; immunoglobulins; intravenous;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Recurrent spontaneous abortion (RSA) has an incidence of 0.5 % -1 %, It is thought that immune reaction disorders in the mother may evolve in unexplained RSA, which has a higher incidence In women over 40 years old. Methods. Twenty-three patients with recurrent spontaneous abortion of unknown origin and two autoimmune cases were treated with intravenous specific immunoglobulins at the 5th-6th week of pregnancy and fifteen days later. Results, After treatment, nineteen patients brought their pregnancy to term, five aborted, one is pregnant at present. Conclusions. The use of immunoglobulins seems to be efficacious in recurrent spontaneous abortion of unknown origin. Our results support the theory that this treatment is able to passively transfer the sparking off factor that allows the pregnancy to evolve.
引用
收藏
页码:193 / 195
页数:3
相关论文
共 50 条
  • [31] Modulatory effect of intravenous immunoglobulin on Th17/Treg cell balance in women with unexplained recurrent spontaneous abortion
    Muyayalo, Kahinho P.
    Li, Zhi-Hui
    Mor, Gil
    Liao, Ai-Hua
    [J]. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2018, 80 (04)
  • [32] The effect of bone marrow mesenchymal stem cells (MSCs) on the recurrent spontaneous abortion (RSA)
    Meng, Y.
    Zhu, X.
    Yan, L.
    Zhang, Y.
    Li, R.
    Qiao, J.
    [J]. HUMAN REPRODUCTION, 2015, 30 : 33 - 33
  • [33] Recurrent Spontaneous Abortion (RSA) and Maternal KIR Genes: A Comprehensive Meta-Analysis
    Akbari, Soheila
    Shahsavar, Farhad
    Karami, Reza
    Yari, Fatemeh
    Anbari, Khatereh
    Ahmadi, Seyyed Amir Yasin
    [J]. JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA, 2020, 24 (02): : 197 - 213
  • [34] The changes of Th9 cells in peripheral blood of patients with alloimmune recurrent spontaneous abortion
    Kang, D.
    Qiao, C.
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 422 - 422
  • [35] A High Dose of Intravenous Immunoglobulin Increases CD94 Expression on Natural Killer Cells in Women with Recurrent Spontaneous Abortion
    Shimada, Shigeki
    Takeda, Masamitsu
    Nishihira, Jun
    Kaneuchi, Masanori
    Sakuragi, Noriaki
    Minakami, Hisanori
    Yamada, Hideto
    [J]. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2009, 62 (05) : 301 - 307
  • [36] The role of killer cell immunoglobulin-like receptors in recurrent spontaneous abortion
    Wright, L
    Williams, F
    Middleton, D
    Sage, D
    [J]. HUMAN IMMUNOLOGY, 2004, 65 : S70 - S70
  • [37] Transmission disequilibrium of maternal CTLA-4 microsatellite alleles in recurrent spontaneous abortion (RSA).
    Tsai, AF
    Walker, MA
    Odem, RR
    Barnes, R
    Scott, JR
    Stephenson, MD
    Schreiber, JR
    Ober, C
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (04) : A20 - A20
  • [38] Are killer immunoglobulin-like receptor genes associated with recurrent spontaneous abortion?
    Nowak, I.
    Luszczek, W.
    Tchorzewski, H.
    Malinowski, A.
    Banasik, M.
    Barcz, E.
    Wilczynski, J.
    Grybos, M.
    Reszczynska-Slezak, D.
    Majorczyk, E.
    Wisniewski, A.
    Senitzer, D.
    Sun, J. Y.
    Kusnierczyk, P.
    [J]. TISSUE ANTIGENS, 2007, 69 (05): : 454 - 454
  • [39] NEOPTERIN AND RECURRENT SPONTANEOUS ABORTION (RSA): THE EFFECT OF CELLULAR IMMUNE SYSTEM ACTIVATION ON SUBSEQUENT PREGNANCY
    Unuvar, Songul
    Tanriverdi, Zubeyde
    [J]. CBU INTERNATIONAL CONFERENCE PROCEEDINGS 2017: INNOVATIONS IN SCIENCE AND EDUCATION, 2017, 5 : 1028 - 1031
  • [40] Prevention of unexplained recurrent spontaneous abortion using intravenous immunoglobulin: A prospective, randomized, double-blinded, placebo-controlled trial
    Stephenson, MD
    Dreher, K
    Houlihan, E
    Wu, V
    [J]. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1998, 39 (02) : 82 - 88