Practical One-Pot C-H Activation/Borylation/Oxidation: Preparation of 3-Bromo-5-methylphenol on a Multigram Scale

被引：11
|
作者：
Norberg, A. Monica [1 ]
Smith, Milton R., III [1 ]
Maleczka, Robert E., Jr. [1 ]
机构：
[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA
来源：
SYNTHESIS-STUTTGART | 2011年 / 06期
关键词：
phenol; C-H activation; borylation; oxidation; boronic ester; IRIDIUM; CHEMISTRY; ARENES;
D O I：
10.1055/s-0030-1258443
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical one-pot C-H activation/borylation/oxidation sequence for the generation of 3,5-disubstituted phenols is presented. Specifically, 3-bromo-5-methylphenol is prepared from 3-bromotoluene, without isolation of intermediates, on a multigram scale, and in high yield. The process proceeds under mild conditions and can be completed within one day.
引用
收藏
页码：857 / 859
页数：3
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