SARS-CoV-2 infection and transmission in the North American deer mouse

被引:70
|
作者
Griffin, Bryan D. [1 ]
Chan, Mable [1 ]
Tailor, Nikesh [1 ]
Mendoza, Emelissa J. [1 ]
Leung, Anders [1 ]
Warner, Bryce M. [1 ,2 ]
Duggan, Ana T. [3 ]
Moffat, Estella [4 ]
He, Shihua [1 ]
Garnett, Lauren [1 ,2 ]
Tran, Kaylie N. [1 ]
Banadyga, Logan [1 ]
Albietz, Alixandra [1 ]
Tierney, Kevin [1 ]
Audet, Jonathan [1 ]
Bello, Alexander [1 ]
Vendramelli, Robert [1 ]
Boese, Amrit S. [1 ]
Fernando, Lisa [1 ]
Lindsay, L. Robbin [1 ,5 ]
Jardine, Claire M. [6 ]
Wood, Heidi [1 ]
Poliquin, Guillaume [2 ,7 ,8 ]
Strong, James E. [1 ,2 ,7 ]
Drebot, Michael [1 ,2 ]
Safronetz, David [1 ,2 ]
Embury-Hyatt, Carissa [4 ]
Kobasa, Darwyn [1 ,2 ]
机构
[1] Publ Hlth Agcy Canada, Natl Microbiol Lab, Zoonot Dis & Special Pathogens Div, Winnipeg, MB, Canada
[2] Univ Manitoba, Coll Med, Fac Hlth Sci, Dept Med Microbiol & Infect Dis, Winnipeg, MB, Canada
[3] Publ Hlth Agcy Canada, Natl Microbiol Lab, Sci Technol Cores & Serv, Winnipeg, MB, Canada
[4] Canadian Food Inspect Agcy, Natl Ctr Foreign Anim Dis, Winnipeg, MB, Canada
[5] Univ Manitoba, Dept Entomol, Winnipeg, MB, Canada
[6] Univ Guelph, Dept Pathobiol, Canadian Wildlife Hlth Cooperat, Guelph, ON, Canada
[7] Univ Manitoba, Coll Med, Fac Hlth Sci, Pediat & Child Hlth, Winnipeg, MB, Canada
[8] Publ Hlth Agcy Canada, Natl Microbiol Labs, Off Sci Director, Winnipeg, MB, Canada
关键词
CORONAVIRUS; MODEL;
D O I
10.1038/s41467-021-23848-9
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Widespread circulation of SARS-CoV-2 in humans raises the theoretical risk of reverse zoonosis events with wildlife, reintroductions of SARS-CoV-2 into permissive nondomesticated animals. Here we report that North American deer mice (Peromyscus maniculatus) are susceptible to SARS-CoV-2 infection following intranasal exposure to a human isolate, resulting in viral replication in the upper and lower respiratory tract with little or no signs of disease. Further, shed infectious virus is detectable in nasal washes, oropharyngeal and rectal swabs, and viral RNA is detectable in feces and occasionally urine. We further show that deer mice are capable of transmitting SARS-CoV-2 to naive deer mice through direct contact. The extent to which these observations may translate to wild deer mouse populations remains unclear, and the risk of reverse zoonosis and/or the potential for the establishment of Peromyscus rodents as a North American reservoir for SARS-CoV-2 remains unknown. Deer mice are natural hosts for a number of human pathogens. Here, Griffin et al. report that intranasal exposure of the North American deer mouse to SARS-CoV-2 results in virus replication and shedding, despite causing only mild or asymptomatic illness. Additionally, infected deer mice can transmit SARS-CoV-2 to naive deer mice.
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页数:10
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