A longitudinal population-based study of predictors of mortality from bloodstream infections in Calgary, Alberta, Canada

被引:1
|
作者
Church, Deirdre [1 ,2 ,3 ]
Somayaji, Ranjani [2 ,4 ,5 ]
Viczko, Jeannine [1 ,3 ]
Gregson, Dan [1 ,2 ,3 ]
Naugler, Christopher [1 ,5 ]
机构
[1] Dept Pathol & Lab Med, Calgary, AB T2N 4N1, Canada
[2] Cumming Sch Med, Dept Med, Calgary, AB T2N 4N1, Canada
[3] Calgary Lab Serv, Microbiol Sect, Dept Clin, Calgary, AB T2N 4N1, Canada
[4] Dept Microbiol Immunol & Infect Dis, Calgary, AB T2N 4N1, Canada
[5] Univ Calgary, Dept Community Hlth Sci, Calgary, AB T2N 4N1, Canada
关键词
bloodstream infections; mortality; pathogen; population based; predictors; time to positivity; CONJUGATE VACCINES; TIME; BACTEREMIA; POSITIVITY; DISEASE; BURDEN; TRENDS; EPIDEMIOLOGY; CULTURES; COUNTY;
D O I
10.2217/fmb-2021-0004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Aim: To study the predictors of mortality from nine major pathogens causing approximately 70% of cases over a 7-year period. Materials & methods: A population-based surveillance cohort of all adult and pediatric patients in the Calgary Zone with an initial episode of bloodstream infections (BSI). Results: The 1-year mortality was 29.2% among 9524 patients (5164 males [54%]). Incidence rates for BSI increased annually to 119.7/100,000 persons by 2016. Distinct survival curves were found for each specific pathogen. Age, comorbidity burden and infecting organism were significantly associated with increased hazard of death. No relationship occurred between the time to positivity for blood cultures and overall mortality. Conclusion: BSI has a high mortality, but overall survival depends on underlying host health and the type of pathogen acquired.
引用
收藏
页码:17 / 25
页数:9
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