Potential biomarkers for differentiation of benign prostatic hyperplasia and prostate cancer

被引：2
|
作者：
El Melegy, N. T. [1 ]
Aboulella, H. A. [2 ]
Abul-Fadl, A. M. [1 ]
Mohamed, N. A. [1 ]
机构：
[1] Assiut Univ, Fac Med, Dept Biochem, Assiut, Egypt
[2] Assiut Univ, Fac Med, Dept Urol, Assiut, Egypt
来源：
BRITISH JOURNAL OF BIOMEDICAL SCIENCE | 2010年 / 67卷 / 03期
关键词：
N-Acetylneuraminic acid; Prostate-specific antigen; Prostatic hyperplasia; Prostatic neoplasms; SERUM SIALIC-ACID; CATHEPSIN-D; ANTIGEN RATIO; MEN; DIAGNOSIS; MARKER; LEVEL; AGE;
D O I：
暂无
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
This study aims to evaluate the role of free/total prostate-specific antigen (PSA) ratio, serum total sialic acid level and cathepsin D activity in the differentiation of prostate cancer and benign prostatic hyperplasia (BPH). The study looked at 100 patients with BPH, 75 patients with organ-confined or locally advanced prostate cancer, and a control group of 50 healthy volunteers. Prostate cancer patients showed significantly higher total sialic acid level and cathepsin D activity and lower free/total PSA ratio than those in the BPH group. The results suggest that combined measurement of serum total sialic acid and/or cathepsin D activity with free/total PSA ratio could serve as a useful adjunct to conventional diagnostics for the differentiation of prostate cancer and BPH.
引用
下载
收藏
页码：109 / 112
页数：4
相关论文
共 50 条
  • [41] Prostatic inflammation is associated with benign prostatic hyperplasia rather than prostate cancer
    Falagario, U.
    Selvaggio, O.
    Carrieri, G.
    Barret, E.
    Sanguedolce, F.
    Cormio, L.
    JOURNAL OF GERONTOLOGY AND GERIATRICS, 2018, 66 (04): : 178 - 182
  • [42] Managing benign prostatic hyperplasia and prostate cancer - the challenges today
    Marberger, Michael
    JOURNAL OF MENS HEALTH, 2010, 7 (02) : 113 - 124
  • [43] Benign prostatic hyperplasia (the aging prostate)
    Medina, JJ
    Parra, RO
    Moore, RG
    MEDICAL CLINICS OF NORTH AMERICA, 1999, 83 (05) : 1213 - +
  • [44] DIAGNOSING BENIGN PROSTATIC HYPERPLASIA VERSUS PROSTATE-CANCER
    DENIS, LJ
    BRITISH JOURNAL OF UROLOGY, 1995, 76 : 17 - 23
  • [45] Androgen Receptor Expression In Benign Prostatic Hyperplasia And Prostate Cancer
    Putriyuni, Anandia
    Liana, Nana
    JOURNAL OF POPULATION THERAPEUTICS AND CLINICAL PHARMACOLOGY, 2023, 30 (05): : E430 - E436
  • [46] Associations of Benign Prostatic Hyperplasia With Prostate Cancer: The Debate Continues
    Kopp, Ryan P.
    Freedland, Stephen J.
    Parsons, J. Kellogg
    EUROPEAN UROLOGY, 2011, 60 (04) : 699 - 700
  • [47] Urinary microbiota in patients with prostate cancer and benign prostatic hyperplasia
    Yu, Haining
    Meng, Hongzhou
    Zhou, Feng
    Ni, Xiaofeng
    Shen, Shengrong
    Das, Undurti N.
    ARCHIVES OF MEDICAL SCIENCE, 2015, 11 (02) : 385 - 394
  • [48] Is garlic a promising food for benign prostatic hyperplasia and prostate cancer?
    Devrim, Erdinc
    Durak, Ilker
    MOLECULAR NUTRITION & FOOD RESEARCH, 2007, 51 (11) : 1319 - 1323
  • [49] OPINION The link between benign prostatic hyperplasia and prostate cancer
    Orsted, David D.
    Bojesen, Stig E.
    NATURE REVIEWS UROLOGY, 2013, 10 (01) : 49 - 54
  • [50] Heat Shock Proteins in Benign Prostatic Hyperplasia and Prostate Cancer
    Ratajczak, Weronika
    Lubkowski, Michal
    Lubkowska, Anna
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (02)
12345