Ca2+ signalling during fertilization of echinoderm eggs

被引:55
|
作者
Jaffe, LA [1 ]
Giusti, AF
Carroll, DJ
Foltz, KR
机构
[1] Univ Connecticut, Ctr Hlth, Dept Physiol, Farmington, CT 06032 USA
[2] Marine Biol Lab, Woods Hole, MA 02543 USA
[3] Florida Inst Technol, Dept Biol Sci, Melbourne, FL 32901 USA
[4] Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
[5] Univ Calif Santa Barbara, Inst Marine Sci, Santa Barbara, CA 93106 USA
基金
美国国家科学基金会;
关键词
calcium; echinoderm; fertilization;
D O I
10.1006/scdb.2000.0216
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The Ca2+ rise at fertilization of echinoderm eggs is initiated by a process requiring the sequential activation of a Src family kinase, phospholipase C gamma, and the inositol trisphosphate receptor/channel in the endoplasmic reticulum. The consequences of the Ca2+ rise include exocytosis of cortical granules which establishes a block to polyspermy and inactivation of MAP kinase, which functions in linking the Ca2+ rise lo the reinitiation of the cell cycle.
引用
收藏
页码:45 / 51
页数:7
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