Imidazo[1,2-a]pyridines: Promising Drug Candidate for Antitumor Therapy

被引：91

作者：

Goel, Richa ^{[1
]}

Luxami, Vijay ^{[1
]}

Paul, Kamaldeep ^{[1
]}

机构：

[1] Thapar Univ, Sch Chem & Biochem, Patiala 147004, Punjab, India

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 30期

关键词：

Antitubulins; Antitumor; Cyclin dependent kinase inhibitors; Imidazo[1,2-a]pyridine; Phosphoinositide-3-kinase inhibitors; Topoisomerase-II inhibitors; 4 TRANS-PLANARAMINEPLATINUM(II) COMPLEXES; PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR; DEPENDENT KINASE INHIBITORS; STRUCTURE-BASED DESIGN; BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; PI3K INHIBITOR; C-MET; HETEROCYCLIC-COMPOUNDS; ANTIULCER AGENTS;

D O I：

10.2174/1568026616666160414122644

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Imidazo[1,2-a] pyridine has been shown to be an important biologically active moiety. This review is a compilation of the scattered output of results of the anticancer activities of the imidazo[1,2-a] pyridine system since 2001, which have been classified as inhibition of CDK, VEGFR, PI3K, EGFR, RGGT etc. along with inhibition against different tumor cell lines. Various imidazo[1,2-a] pyridine based analogues have been used as lead molecules and are now under human clinical trials. This review will help the wider scientific community in the area of drug discovery of imidazo[1,2-a] pyridines as novel anticancer agents.

引用

页码：3590 / 3616

页数：27

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