New route for the activation of poly(ADP-ribose) polymerase-1: a passage that links poly(ADP-ribose) polymerase-1 to lipotoxicity?

被引：3
|
作者：
Bai, Peter [1 ,2 ,3 ]
Csoka, Balazs [4 ,5 ]
机构：
[1] Univ Debrecen, Dept Med Chem, H-4032 Debrecen, Hungary
[2] MTA DE Lendulet Lab Cellular Metab Res Grp, H-4032 Debrecen, Hungary
[3] Univ Debrecen, Res Ctr Mol Med, H-4032 Debrecen, Hungary
[4] Rutgers State Univ, Dept Surg, New Jersey Med Sch, Newark, NJ 07103 USA
[5] Rutgers State Univ, Ctr Immun & Inflammat, New Jersey Med Sch, Newark, NJ 07103 USA
来源：
BIOCHEMICAL JOURNAL | 2015年 / 469卷
关键词：
ACBD3; cholesterol; ERK; fatty acid; lipotoxicity; PARP; DIFFERENTIATION; EXPRESSION; BINDING; ACBD3; DNA;
D O I：
10.1042/BJ20150598
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of Biochemical Journal, Chen and colleagues characterize an interaction between ACBD3 (acyl-CoA-binding domain-containing 3) protein and PARP [poly(ADP-ribose) polymerase]-1 through the activation of ERKs (extracellular-signal-regulated kinases). This study envisages a pathway through which ABCD3 translates enhanced fatty acid levels to ERK and consequently PARP-1 activation. The consequences of PARP-1 activation lead to cellular and tissue damage, implying that the ACBD3/PARP-1 pathway is an important pathway in lipotoxicity events.
引用
收藏
页码：E9 / E11
页数：3
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