Review on fluorinated nucleoside/non-nucleoside FDA-approved antiviral drugs

被引：9

作者：

Ismail, Magda M. F. ^{[1
]}

Ayoup, Mohammed Salah ^{[2
]}

机构：

[1] Al Azhar Univ, Fac Pharm Girls, Dept Pharmaceut Med Chem & Drug Design, Cairo 11754, Egypt

[2] Alexandria Univ, Fac Sci, Dept Chem, POB 426, Alexandria 21321, Egypt

来源：

RSC ADVANCES | 2022年 / 12卷 / 48期

关键词：

MEDICINAL CHEMISTRY; ANTIRETROVIRAL THERAPY; REVERSE-TRANSCRIPTASE; T-705; FAVIPIRAVIR; INHIBITORS; RESISTANCE; ANALOGS; REPLICATION; TIPRANAVIR; ANTICANCER;

D O I：

10.1039/d2ra05370e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

FDA-approved antiviral agents represent an important class that has attracted attention in recent years to combat current and future threats of viral pandemics. Fluorine ameliorates the electronic, lipophilic and steric problems of drugs. Additionally, fluorine can prolong drug activity and improve metabolic stability, thereby, modifying their pharmacodynamic and pharmacokinetic character. Herein, we summarized the fluorinated FDA-approved antiviral agents, dealing with biological aspects, mechanisms of action, and synthetic pathways.

引用

页码：31032 / 31045

页数：14

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