The role of decidual immune cells on human pregnancy

被引：228

作者：

Liu, Su ^{[1
]}

Diao, Lianghui ^{[1
,2
]}

Huang, Chunyu ^{[1
,3
]}

Li, Yuye ^{[1
]}

Zeng, Yong ^{[1
]}

Kwak-Kim, Joanne Y. H. ^{[4
,5
]}

机构：

[1] Shenzhen Zhongshan Urol Hosp, Shenzhen Key Lab Reprod Immunol Peri Implantat, Shenzhen Zhongshan Inst Reprod Med & Genet, Fertil Ctr, Shenzhen, Peoples R China

[2] Univ Med Ctr Hamburg Eppendorf, Dept Obstet & Fetal Med, Lab Expt Fetomaternal Med, Hamburg, Germany

[3] Univ Hong Kong, Dept Paediat & Adolescent Med, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China

[4] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Obstet & Gynecol, Reprod Med & Immunol, Vernon Hills, IL USA

[5] Rosalind Franklin Univ Med & Sci, Dept Microbiol & Immunol, Chicago Med Sch, N Chicago, IL USA

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2017年 / 124卷

基金：

中国国家自然科学基金;

关键词：

Pregnancy; NK cells; Macrophages; Dendritic cells; T cells; REGULATORY T-CELLS; NATURAL-KILLER-CELLS; ANTIGEN-PRESENTING CELLS; IMMUNOGLOBULIN-LIKE RECEPTORS; FETAL-MATERNAL INTERFACE; UTERINE NK CELLS; DENDRITIC CELLS; PERIPHERAL-BLOOD; HLA-G; CD94/NKG2; RECEPTORS;

D O I：

10.1016/j.jri.2017.10.045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and develop in the uterus, despite being recognized by the maternal immune cells. Within the innate immune system, decidual natural killer cells and antigen presenting cells (including macrophages and dendritic cells) that comprise a large proportion of the decidual leukocyte populations play an important role in modulating trophoblast invasion, angiogenesis and vascular remodeling. On the other hand, within the adaptive immune system, CD8(+) T cells, effector CD4(+) T cells, Foxp3(+) regulatory T cells and CD4(+)HLA-G(+) suppressor T cells are identified as potential players in maintaining immune tolerance toward the semi-allogeneic fetus. This review discusses how these key immune cells contribute to pregnancy outcome and the complex interactions between the innate and adaptive immune system during human pregnancy.

引用

页码：44 / 53

页数：10

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