Recognition and function of Vα14 NKT cells

被引：70
|
作者：
Taniguchi, M [1 ]
Nakayama, T [1 ]
机构：
[1] Chiba Univ, Grad Sch Med, CREST, Chuo Ku, Chiba 2608670, Japan
来源：
SEMINARS IN IMMUNOLOGY | 2000年 / 12卷 / 06期
关键词：
alpha-galactosylceramide; GM-CSF; invariant TCR; gene rearrangement; tumor rejection;
D O I：
10.1006/smim.2000.0270
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A novel lymphocyte lineage, V alpha 14 NKT cells, has recently been identified and appears to be distinct from conventional alpha beta T cells. V alpha 14 NKT cells express a single invariant V alpha 14 antigen receptor that is essential for their development. They recognize a glycolipid antigen (alpha -galactasylceramide) or parasitic glycophosphatidylinositols (GPI) in association with a monomorphic class Ib, CD1d, and perform various functions such as Th1 and Th2 cytokine production as well as perform/granzyme B-mediated cytotoxicity. Although the precise physiological function of Vor 14 NKT cells remains to be elucidated, emerging experimental evidence suggests their intriguing regulatory features in the immune system.
引用
收藏
页码：543 / 550
页数：8
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