Development and evaluation of Eudragit coated environmental sensitive solid lipid nanoparticles using central composite design module for enhancement of oral bioavailability of linagliptin

被引：21
|
作者：
Veni, D. Krishna [1 ]
Gupta, N. Vishal [1 ]
机构：
[1] JSS Coll Pharm, Dept Pharmaceut, Mysuru, India
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2020年 / 69卷 / 07期
关键词：
Central composite deign; linagliptin; pharmacokinetic study; response surface methodology; solid lipid nanoparticles; CARRIERS; THERAPY;
D O I：
10.1080/00914037.2019.1570513
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Linagliptin is a DPP-4 Inhibitor used in the treatment of Type II Diabetes. One of the major disadvantages of this drug is low bioavailability. To overcome this challenge a new drug delivery has been developed for this drug, enteric coating the drug with pH sensitive polymer and formulated as Solid Lipid Nanoparticles (SLN's) using central composite design module exploiting Design of Expert (R) 11 software. Further a validated RP-HPLC method was developed to investigate the pharmacokinetic parameters of the drug and SLN's. The pharmacokinetic study revealed that oral bioavailability of Linagliptin was enhanced by SLN's when compared to the pure drug.
引用
收藏
页码：407 / 418
页数：12
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