Noncanonical structural elements of promoter DNA and their role in complex formation with RNA polymerase

被引：0
|
作者：
Ozoline, ON [1 ]
Deev, AA
机构：
[1] Russian Acad Sci, Inst Cell Biophys, Pushchino 142292, Moscow Region, Russia
[2] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142292, Russia
来源：
MOLECULAR BIOLOGY | 1998年 / 32卷 / 03期
关键词：
promoter structure; cluster analysis; RNA polymerase; noncanonical signal elements;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Promoter sequences were studied by cluster analysis, Five regions with nonrandom base distribution were found, and their typical structural elements were revealed, Some of these elements were homologous to the sequences located near the promoter regions, which, in a complex with RNA polymerase, displayed hypersensitivity to DNase I. Since near such sites the enzyme tightly contacts the promoter DNA, the physicochemical features of the found sequences may determine the specificity of the interaction of RNA polymerase with different promoters.
引用
收藏
页码：358 / 362
页数：5
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