Acoustic Wave Sparsely-Activated Localization Microscopy (AWSALM): In Vivo Fast Ultrasound Super-Resolution Imaging using Nanodroplets

被引：0

作者：

Zhang, Ge ^{[1
]}

Harput, Sevan ^{[1
,2
]}

Toulemonde, Matthieu ^{[1
]}

Broughton-Venner, Jacob ^{[1
]}

Zhu, Jiaqi ^{[1
]}

Riemer, Kai ^{[1
]}

Christensen-Jeffries, Kirsten ^{[3
]}

Brown, Jemma ^{[3
]}

Eckersley, Robert J. ^{[3
]}

Weinberg, Peter ^{[1
]}

Dunsby, Chris ^{[4
,5
]}

Tang, Meng-Xing ^{[1
]}

机构：

[1] Imperial Coll London, Dept Bioengn, London SW7 2AZ, England

[2] London South Bank Univ, Div Elect & Elect Engn, London SE1 0AA, England

[3] Kings Coll London, Sch Biomed Engn & Imaging Sci, Biomed Engn Dept, London SE1 7EH, England

[4] Imperial Coll London, Dept Phys, London SW7 2AZ, England

[5] Imperial Coll London, Ctr Pathol, London SW7 2AZ, England

来源：

2019 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) | 2019年

基金：

英国工程与自然科学研究理事会;

关键词：

Super-Resolution; Decafluorobutane Nanodroplets; High Frame Rate; Flow Independent; Microbubbles;

D O I：

10.1109/ultsym.2019.8926069

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Current localization-based super-resolution ultrasound imaging requires a low concentration of flowing microbubbles to visualize microvasculature beyond the diffraction limit and acquisition is slow. Nanodroplets offer a promising solution as they can be sparsely activated and deactivated on-demand. In this study, acoustic wave sparsely-activated localization microscopy (AWSALM) using activation and deactivation of nanodroplets, an acoustic counterpart of photo-activated localization microscopy (PALM) which is less dependent on agent concentration and the presence of flow, is demonstrated for super-resolution imaging in deep tissues in vivo. An in vivo super-resolution image of a rabbit kidney is obtained in 1.1 seconds using AWSALM, where micro-vessels with apparent sizes far below the half-wavelength of 220 mu m were visualized. This preliminary result demonstrates the feasibility of applying AWSALM for in vivo super-resolution imaging.

引用

页码：1930 / 1933

页数：4

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